Ziprasidone treatment of children and adolescents with Tourette's syndrome: A pilot study

Floyd R. Sallee, Roger Kurlan, Christopher G. Goetz, Harvey Singer, Lawrence Scahill, Gordon Law, Valerie M. Dittman, Phillip B. Chappell

Research output: Contribution to journalArticlepeer-review

274 Scopus citations


Objective: To evaluate the efficacy and tolerability of ziprasidone in children and adolescents with Tourette's syndrome and chronic tic disorders. Method: Twenty-eight patients aged 7 to 17 years were randomly assigned to ziprasidone or placebo for 56 days. Ziprasidone was initiated at a dose of 5 mg/day and flexibly titrated to a maximum of 40 mg/day. Results: Ziprasidone was significantly more effective than placebo in reducing the Global Severity (p = .016) and Total Tic (p = .008) scores on the Yale Global Tic Severity Scale. Compared with placebo, ziprasidone significantly reduced tic frequencies as determined by blind videotape tic counts (p = .039). The mean (±SD) daily dose of ziprasidone during the last 4 weeks of the trial was 28.2 ± 9.6 mg. Mild transient somnolence was the most common adverse event. No clinically significant effects were observed on specific ratings of extrapyramidal symptoms, akathisia, or tardive dyskinesia. Conclusions: In this limited sample, ziprasidone (5-40 mg/day) appears to be effective and well tolerated in the treatment of Tourette's syndrome. Ziprasidone may be associated with a lower risk of extrapyramidal side effects in children. However, additional studies are necessary to evaluate more fully its safety and efficacy in children with tic disorders.

Original languageEnglish (US)
Pages (from-to)292-299
Number of pages8
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Issue number3
StatePublished - 2000


  • Antipsychotic agents
  • Tics
  • Tourette's syndrome
  • Ziprasidone

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health


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