YAC transgenics and the study of genetics and human disease

Bruce T. Lamb, John D. Gearhart

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Advances in yeast artificial chromosome (YAC) technologies over the past decade have enabled the precise identification and manipulation of large genomic regions (>100 kb) of DNA. Introduction of YACs into the mouse germline has now been accomplished through transfection of mouse embryonic stem cells as well as through pronuclear microinjection, allowing the efficient transfer of defined genomic loci into mice. YAC transgenics will have a profound impact on the development of transgenic mice as bioreactors and as models of human disease, and on the functional analysis of higher order genomic structure.

Original languageEnglish (US)
Pages (from-to)342-348
Number of pages7
JournalCurrent Opinion in Genetics and Development
Issue number3
StatePublished - 1995

ASJC Scopus subject areas

  • Developmental Biology
  • Genetics


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