XRN1: A Major 5' to 3' Exoribonuclease in Eukaryotic Cells

Sarah Geisler, Jeff Coller

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations


The degradation of RNA is a critical aspect of gene regulation. Correspondingly, ribonucleases exist within the cell to degrade RNA in specific cellular contexts. An important and conserved ribonuclease is called XRN1. This enzyme, an exoribonuclease, degrades RNA in a processive 5' to 3' direction. Substrates for XRN1 include decapped mRNA, endonucleolytically cleaved mRNA, lncRNA, and some aberrant tRNAs. In addition, XRN1 serves a vital role in the processing and maturation of the 5' ends of rRNA and snoRNAs. In this review, we discuss some of the important roles of XRN1 in the cell.

Original languageEnglish (US)
Title of host publicationEnzymes
PublisherAcademic Press
Number of pages18
StatePublished - 2012
Externally publishedYes

Publication series

ISSN (Print)1874-6047


  • Ribonuclease
  • RNA degradation
  • RNA stability
  • RNA turnover
  • XRN1

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biochemistry
  • Molecular Biology


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