X-ray microbeams: Tumor therapy and central nervous system research

F. A. Dilmanian, Y. Qu, S. Liu, C. D. Cool, J. Gilbert, J. F. Hainfeld, C. A. Kruse, J. Laterra, D. Lenihan, M. M. Nawrocky, G. Pappas, C. I. Sze, T. Yuasa, N. Zhong, Z. Zhong, J. W. McDonald

Research output: Contribution to journalConference articlepeer-review

51 Scopus citations


Irradiation with parallel arrays of thin, planar slices of X-ray beams (microplanar beams, or microbeams) spares normal tissue, including the central nervous system (CNS), and preferentially damages tumors. The effects are mediated, at least in part, by the tissue's microvasculature that seems to effectively repair itself in normal tissue but fails to do so in tumors. Consequently, the therapeutic index of single-fraction unidirectional microbeam irradiations has been shown to be larger than that of single-fraction unidirectional unsegmented beams in treating the intracranial rat 9L gliosarcoma tumor model (9LGS) and the subcutaneous murine mammary carcinoma EMT-6. This paper presents results demonstrating that individual microbeams, or arrays of parallel ones, can also be used for targeted, selective cell ablation in the CNS, and also to induce demyelination. The results highlight the value of the method as a powerful tool for studying the CNS through selective cell ablation, besides its potential as a treatment modality in clinical oncology.

Original languageEnglish (US)
Pages (from-to)30-37
Number of pages8
JournalNuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Issue number1-2
StatePublished - Aug 11 2005
Externally publishedYes
EventProceedings of the 4th International Worhshop on Medical Applications of Synchrotron Radiation MASR 2004 -
Duration: Sep 23 2005Sep 25 2005


  • Dosimetry
  • Micro-beam therapy
  • Synchrotron radiation

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Instrumentation


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