TY - JOUR
T1 - Workshop report
T2 - Developing microphysiological systems for use as regulatory tools
AU - Andersen, Melvin E.
AU - Betts, Kellyn
AU - Dragan, Yvonne
AU - Fitzpatrick, Suzanne
AU - Goodman, Jesse L.
AU - Hartung, Thomas
AU - Himmelfarb, Jonathan
AU - Ingber, Donald E.
AU - Jacobs, Abigail
AU - Kavlock, Robert
AU - Kolaja, Kyle
AU - Stevens, James L.
AU - Tagle, Dan
AU - Taylor, D. Lansing
AU - Throckmorton, Douglas
N1 - Publisher Copyright:
© 2014, Elsevier GmbH. All rights reserved.
PY - 2014
Y1 - 2014
N2 - In the last few years, scientists have made progress in developing systems using human cells to test the effects of drugs and other substances. These systems are known as microsystems, microphysiological systems, or organs-on-a-chip. They have the potential to improve toxicity testing beyond currently available tools and to reduce the number of animals used. On May 10, 2013 scientists in academia, industry and regulatory agencies met in person and online to discuss the essential elements needed to develop these systems for use as regulatory tools, as well as pathways to their qualification. The one-day workshop was co-sponsored by the Food and Drug Administration, National Institutes of Health, National Institute for Environmental Health Sciences, National Center for Advancing Translational Science, Environmental Protection Agency, Johns Hopkins School of Public Health's Center for Alternatives to Animal Testing and the International Consortium for Innovation and Quality in Pharmaceutical Development.
AB - In the last few years, scientists have made progress in developing systems using human cells to test the effects of drugs and other substances. These systems are known as microsystems, microphysiological systems, or organs-on-a-chip. They have the potential to improve toxicity testing beyond currently available tools and to reduce the number of animals used. On May 10, 2013 scientists in academia, industry and regulatory agencies met in person and online to discuss the essential elements needed to develop these systems for use as regulatory tools, as well as pathways to their qualification. The one-day workshop was co-sponsored by the Food and Drug Administration, National Institutes of Health, National Institute for Environmental Health Sciences, National Center for Advancing Translational Science, Environmental Protection Agency, Johns Hopkins School of Public Health's Center for Alternatives to Animal Testing and the International Consortium for Innovation and Quality in Pharmaceutical Development.
KW - Microphysiological systems
KW - Organs-on-a-chip
UR - http://www.scopus.com/inward/record.url?scp=84989809033&partnerID=8YFLogxK
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U2 - 10.14573/altex.1405151s
DO - 10.14573/altex.1405151s
M3 - Review article
AN - SCOPUS:84989809033
SN - 1868-596X
VL - 31
JO - ALTEX : Alternativen zu Tierexperimenten
JF - ALTEX : Alternativen zu Tierexperimenten
ER -