TY - JOUR
T1 - Word picture verification performance reveals auditory comprehension deficits in primary progressive aphasia
AU - Suh, Samuel
AU - DeLuque, Elizabeth
AU - Kelly, Catherine
AU - Lee, Xander
AU - Mace, Rachel Fabian
AU - Ruch, Kristina
AU - Sharif, Massoud
AU - Stockbridge, Melissa D.
AU - Vitti, Emilia
AU - Tippett, Donna C.
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2023/2
Y1 - 2023/2
N2 - Word/picture verification has been found to be a sensitive measure of lexical-semantic abilities in post-stroke aphasia and reveals information about disruptions in semantic and phonological processing. Exploration of the nature of auditory comprehension deficits using word/picture verification has not been replicated in primary progressive aphasia (PPA). We tested 108 individuals with PPA [logopenic variant PPA (lvPPA), n = 50; nonfluent agrammatic PPA (nfaPPA), n = 36; semantic variant PPA (svPPA), n = 22] on a spoken word/picture verification task and a spoken word/picture matching task. The spoken word/picture matching task identified 22 (20%) of individuals as impaired, whereas the spoken word/picture verification task identified 51 (47%) of individuals as impaired (two-tailed p < 0.001). Errors on spoken word/picture verification were due to semantic rather than phonologic foils in lvPPA (nouns, p < 0.001; verbs, p < 0.001), svPPA (nouns, p < 0.001; verbs, p < 0.001), and for nouns (p = 0.001) but not verbs in nfaPPA. Spoken word/picture verification was a more sensitive measure of single-word auditory comprehension deficits in PPA than word/picture matching. The error pattern, consistent with the distributed model of semantic knowledge, suggests that degradation of semantic representations for both nouns and verbs can occur in lvPPA, which may help to distinguish lvPPA versus nfaPPA and guide treatment for anomia.
AB - Word/picture verification has been found to be a sensitive measure of lexical-semantic abilities in post-stroke aphasia and reveals information about disruptions in semantic and phonological processing. Exploration of the nature of auditory comprehension deficits using word/picture verification has not been replicated in primary progressive aphasia (PPA). We tested 108 individuals with PPA [logopenic variant PPA (lvPPA), n = 50; nonfluent agrammatic PPA (nfaPPA), n = 36; semantic variant PPA (svPPA), n = 22] on a spoken word/picture verification task and a spoken word/picture matching task. The spoken word/picture matching task identified 22 (20%) of individuals as impaired, whereas the spoken word/picture verification task identified 51 (47%) of individuals as impaired (two-tailed p < 0.001). Errors on spoken word/picture verification were due to semantic rather than phonologic foils in lvPPA (nouns, p < 0.001; verbs, p < 0.001), svPPA (nouns, p < 0.001; verbs, p < 0.001), and for nouns (p = 0.001) but not verbs in nfaPPA. Spoken word/picture verification was a more sensitive measure of single-word auditory comprehension deficits in PPA than word/picture matching. The error pattern, consistent with the distributed model of semantic knowledge, suggests that degradation of semantic representations for both nouns and verbs can occur in lvPPA, which may help to distinguish lvPPA versus nfaPPA and guide treatment for anomia.
KW - Auditory comprehension
KW - Phonologic
KW - Primary progressive aphasia
KW - Semantic
UR - http://www.scopus.com/inward/record.url?scp=85141256527&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85141256527&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroling.2022.101116
DO - 10.1016/j.jneuroling.2022.101116
M3 - Article
AN - SCOPUS:85141256527
SN - 0911-6044
VL - 65
JO - Journal of Neurolinguistics
JF - Journal of Neurolinguistics
M1 - 101116
ER -