Word picture verification performance reveals auditory comprehension deficits in primary progressive aphasia

Samuel Suh, Elizabeth DeLuque, Catherine Kelly, Xander Lee, Rachel Fabian Mace, Kristina Ruch, Massoud Sharif, Melissa D. Stockbridge, Emilia Vitti, Donna C. Tippett

Research output: Contribution to journalArticlepeer-review


Word/picture verification has been found to be a sensitive measure of lexical-semantic abilities in post-stroke aphasia and reveals information about disruptions in semantic and phonological processing. Exploration of the nature of auditory comprehension deficits using word/picture verification has not been replicated in primary progressive aphasia (PPA). We tested 108 individuals with PPA [logopenic variant PPA (lvPPA), n = 50; nonfluent agrammatic PPA (nfaPPA), n = 36; semantic variant PPA (svPPA), n = 22] on a spoken word/picture verification task and a spoken word/picture matching task. The spoken word/picture matching task identified 22 (20%) of individuals as impaired, whereas the spoken word/picture verification task identified 51 (47%) of individuals as impaired (two-tailed p < 0.001). Errors on spoken word/picture verification were due to semantic rather than phonologic foils in lvPPA (nouns, p < 0.001; verbs, p < 0.001), svPPA (nouns, p < 0.001; verbs, p < 0.001), and for nouns (p = 0.001) but not verbs in nfaPPA. Spoken word/picture verification was a more sensitive measure of single-word auditory comprehension deficits in PPA than word/picture matching. The error pattern, consistent with the distributed model of semantic knowledge, suggests that degradation of semantic representations for both nouns and verbs can occur in lvPPA, which may help to distinguish lvPPA versus nfaPPA and guide treatment for anomia.

Original languageEnglish (US)
Article number101116
JournalJournal of Neurolinguistics
StatePublished - Feb 2023


  • Auditory comprehension
  • Phonologic
  • Primary progressive aphasia
  • Semantic

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Arts and Humanities (miscellaneous)
  • Linguistics and Language
  • Cognitive Neuroscience


Dive into the research topics of 'Word picture verification performance reveals auditory comprehension deficits in primary progressive aphasia'. Together they form a unique fingerprint.

Cite this