Wiring the angiogenic switch: Ras, myc, and thrombospondin-1

Olga V. Volpert, Rhoda M. Alani

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The formation of a blood supply is critical for tumor growth and metastasis; however, understanding the relationship of cellular transformation to tumor angiogenesis has been limited by the multifactorial nature of both processes. In this issue of Cancer Cell, Watnick and colleagues use a genetically defined tumor model system to determine the link between ras, myc, and angiogenesis and identify Thrombospondin-1 as being the critical regulator of angiogenesis in this system (Watnick et al., 2003).

Original languageEnglish (US)
Pages (from-to)199-200
Number of pages2
JournalCancer Cell
Issue number3
StatePublished - Mar 2003

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology


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