TY - JOUR
T1 - Wireless multichannel biopotential recording using an integrated FM telemetry circuit
AU - Mohseni, Pedram
AU - Najafi, Khalil
AU - Eliades, Steven J.
AU - Wang, Xiaoqin
N1 - Funding Information:
Manuscript received December 8, 2005; revised April 5, 2005; accepted May 13, 2005. The biological experiments were conducted in the Laboratory of Auditory Neurophysiology at Johns Hopkins University (supported under the National Institutes of Health Grant R01-DC005808). This work was supported under the National Institutes of Health Grant R01-DC04198-01. This work also made use of Engineering Research Center Shared Facilities supported by the National Science Foundation under Award EEC-0096866.
PY - 2005/9
Y1 - 2005/9
N2 - This paper presents a four-channel telemetric microsystem featuring on-chip alternating current amplification, direct current baseline stabilization, clock generation, time-division multiplexing, and wireless frequency-modulation transmission of microvolt- and millivolt-range input biopotentials in the very high frequency band of 94-98 MHz over a distance of ∼ 0.5 m. It consists of a 4.84-mm2 integrated circuit, fabricated using a 1.5-μm double-poly double-metal n-well standard complementary metal-oxide semiconductor process, interfaced with only three off-chip components on a custom-designed printed-circuit board that measures 1.7 × 1.2 × 0.16 cm3, and weighs 1.1 g including two miniature 1.5-V batteries. We characterize the microsystem performance, operating in a truly wireless fashion in single-channel and multichannel operation modes, via extensive benchtop and in vitro tests in saline utilizing two different micromachined neural recording microelectrodes, while dissipating ∼ 2.2 mW from a 3-V power supply. Moreover, we demonstrate successful wireless in vivo recording of spontaneous neural activity at 96.2 MHz from the auditory cortex of an awake marmoset monkey at several transmission distances ranging from 10 to 50 cm with signal-to-noise ratios in the range of 8.4-9.5 dB.
AB - This paper presents a four-channel telemetric microsystem featuring on-chip alternating current amplification, direct current baseline stabilization, clock generation, time-division multiplexing, and wireless frequency-modulation transmission of microvolt- and millivolt-range input biopotentials in the very high frequency band of 94-98 MHz over a distance of ∼ 0.5 m. It consists of a 4.84-mm2 integrated circuit, fabricated using a 1.5-μm double-poly double-metal n-well standard complementary metal-oxide semiconductor process, interfaced with only three off-chip components on a custom-designed printed-circuit board that measures 1.7 × 1.2 × 0.16 cm3, and weighs 1.1 g including two miniature 1.5-V batteries. We characterize the microsystem performance, operating in a truly wireless fashion in single-channel and multichannel operation modes, via extensive benchtop and in vitro tests in saline utilizing two different micromachined neural recording microelectrodes, while dissipating ∼ 2.2 mW from a 3-V power supply. Moreover, we demonstrate successful wireless in vivo recording of spontaneous neural activity at 96.2 MHz from the auditory cortex of an awake marmoset monkey at several transmission distances ranging from 10 to 50 cm with signal-to-noise ratios in the range of 8.4-9.5 dB.
KW - In vivo neural recording
KW - Multichannel biotelemetry
KW - Neural prostheses
KW - Wireless frequency-modulation (FM) microsystem
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U2 - 10.1109/TNSRE.2005.853625
DO - 10.1109/TNSRE.2005.853625
M3 - Article
C2 - 16200750
AN - SCOPUS:26244468380
SN - 1534-4320
VL - 13
SP - 263
EP - 271
JO - IEEE Transactions on Neural Systems and Rehabilitation Engineering
JF - IEEE Transactions on Neural Systems and Rehabilitation Engineering
IS - 3
ER -