Wide-range, picoampere-sensitivity multichannel VLSI potentiostat for neurotransmitter sensing

Kartikeya Murari; Nitish Thakor; Milutin Stanacevic; Gert Cauwenberghs

Wide-range, picoampere-sensitivity multichannel VLSI potentiostat for neurotransmitter sensing

Kartikeya Murari, Nitish Thakor, Milutin Stanacevic, Gert Cauwenberghs

School of Medicine

Research output: Contribution to journal › Conference article › peer-review

25 Scopus citations

Abstract

Neurotransmitter sensing is critical in studying nervous pathways and neurological disorders. A 16-channel current-measuring VLSI potentiostat with multiple ranges from picoamperes to microamperes is presented for electrochemical detection of electroactive neurotransmitters like dopamine, nitric oxide etc. The analog-to-digital converter design employs a current-mode, first-order single-bit delta-sigma modulator architecture with a two-stage, digitally reconflgurable oversampling ratio for ranging the conversion scale. An integrated prototype is fabricated in CMOS technology, and experimentally characterized. Real-time multi-channel acquisition of dopamine concentration in vitro is performed with a microfabricated sensor array.

Original language	English (US)
Pages (from-to)	4063-4066
Number of pages	4
Journal	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	26 VI
State	Published - Dec 1 2004
Event	Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States Duration: Sep 1 2004 → Sep 5 2004

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

Cite this

Wide-range, picoampere-sensitivity multichannel VLSI potentiostat for neurotransmitter sensing. / Murari, Kartikeya; Thakor, Nitish; Stanacevic, Milutin et al.
In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Vol. 26 VI, 01.12.2004, p. 4063-4066.

Research output: Contribution to journal › Conference article › peer-review

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AU - Cauwenberghs, Gert

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Wide-range, picoampere-sensitivity multichannel VLSI potentiostat for neurotransmitter sensing

Abstract

ASJC Scopus subject areas

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