Why is cancer drug discovery so difficult?

Alexander Kamb, Susan Wee, Christoph Lengauer

Research output: Contribution to journalArticlepeer-review

254 Scopus citations


Thirty-five years after the 'war on cancer' was declared, the discovery of anticancer drugs remains a highly challenging endeavour. Here, we consider the factors responsible, such as tumour heterogeneity, and suggest strategies to improve the chances of short-term success in the development of novel anticancer drugs.

Original languageEnglish (US)
Pages (from-to)115-120
Number of pages6
JournalNature Reviews Drug Discovery
Issue number2
StatePublished - Feb 2007
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


Dive into the research topics of 'Why is cancer drug discovery so difficult?'. Together they form a unique fingerprint.

Cite this