Common references to the famous two-hit hypothesis of tumorigenesis are pervasively erroneous, and the recited tenets of this model vary enormously. Exploration of the history of this model reveals a rich philosophical progression that profited from perceptive observations, clever musings, and rediscoveries by many investigators over a period of decades. The current work is intended to raise the appreciation for this rich history and to address some of the more common errors.
|Original language||English (US)|
|Number of pages||11|
|Journal||Cancer Biology and Therapy|
|State||Published - Sep 2002|
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research