Abstract
Common references to the famous two-hit hypothesis of tumorigenesis are pervasively erroneous, and the recited tenets of this model vary enormously. Exploration of the history of this model reveals a rich philosophical progression that profited from perceptive observations, clever musings, and rediscoveries by many investigators over a period of decades. The current work is intended to raise the appreciation for this rich history and to address some of the more common errors.
Original language | English (US) |
---|---|
Pages (from-to) | 571-581 |
Number of pages | 11 |
Journal | Cancer Biology and Therapy |
Volume | 1 |
Issue number | 5 |
DOIs | |
State | Published - Sep 2002 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine
- Oncology
- Pharmacology
- Cancer Research