Whole-Organ Genomic Characterization of Mucosal Field Effects Initiating Bladder Carcinogenesis

Tadeusz Majewski, Hui Yao, Jolanta Bondaruk, Woonbok Chung, Sangkyou Lee, June Goo Lee, Shizhen Zhang, David Cogdell, Guoliang Yang, Woonyoung Choi, Colin Dinney, H. Barton Grossman, Christopher Logothetis, Steven E. Scherer, Charles C. Guo, Li Zhang, Peng Wei, John N. Weinstein, Jean Pierre Issa, Keith BaggerlyDavid J. McConkey, Bogdan Czerniak

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Majewski et al. report that methylation changes suppressing innate immunity and dysregulating Ras-related pathways initiate bladder carcinogenesis.

Original languageEnglish (US)
Pages (from-to)2241-2256.e4
JournalCell Reports
Issue number8
StatePublished - Feb 19 2019


  • DNA copy alterations
  • DNA methylation
  • Whole-organ map
  • bladder cancer
  • clonal expansion
  • clonal origins
  • field effect
  • founder mutation
  • gene signature
  • urothelial carcinoma

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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