@article{4186e0d0bcc640e1ab3d1099784a6b51,
title = "Whole-Organ Genomic Characterization of Mucosal Field Effects Initiating Bladder Carcinogenesis",
abstract = "Majewski et al. report that methylation changes suppressing innate immunity and dysregulating Ras-related pathways initiate bladder carcinogenesis.",
keywords = "DNA copy alterations, DNA methylation, Whole-organ map, bladder cancer, clonal expansion, clonal origins, field effect, founder mutation, gene signature, urothelial carcinoma",
author = "Tadeusz Majewski and Hui Yao and Jolanta Bondaruk and Woonbok Chung and Sangkyou Lee and Lee, {June Goo} and Shizhen Zhang and David Cogdell and Guoliang Yang and Woonyoung Choi and Colin Dinney and Grossman, {H. Barton} and Christopher Logothetis and Scherer, {Steven E.} and Guo, {Charles C.} and Li Zhang and Peng Wei and Weinstein, {John N.} and Issa, {Jean Pierre} and Keith Baggerly and McConkey, {David J.} and Bogdan Czerniak",
note = "Funding Information: This study was supported by National Cancer Institute (NCI) Genitourinary Bladder SPORE Grant P50CA 91846 (Project 1 and Core C to B.C.). Publisher Copyright: {\textcopyright} 2019 The Author(s)",
year = "2019",
month = feb,
day = "19",
doi = "10.1016/j.celrep.2019.01.095",
language = "English (US)",
volume = "26",
pages = "2241--2256.e4",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "8",
}