TY - JOUR
T1 - Whole grains are associated with serum concentrations of high sensitivity C-reactive protein among premenopausal women
AU - Gaskins, Audrey J.
AU - Mumford, Sunni L.
AU - Rovner, Alisha J.
AU - Zhang, Cuilin
AU - Chen, Liwei
AU - Wactawski-Wende, Jean
AU - Perkins, Neil J.
AU - Schisterman, Enrique F.
PY - 2010/9
Y1 - 2010/9
N2 - In premenopausal women, elevated C-reactive protein (CRP) concentrations have been associated with an increased risk of negative reproductive outcomes. Whole grain consumption has been associated with lower CRP concentrations in older women; however, less is known about this relationship in younger women. We investigated whether whole grain intake was associated with serum high sensitivity CRP (hs-CRP) concentrations in young women. BioCycle was a prospective cohort study conducted at the University of Buffalo from 2005 to 2007, which followed 259 healthy women aged 18-44 y for ≤2 menstrual cycles. hs-CRP concentrations were measured longitudinally ≤8 times/cycle with visits standardized to menstrual cycle phase. Whole grain intake was estimated by 24-h recalls ≤4 times/cycle. Servings were defined as 16 g or 125 mL of a 100% whole grain food. Whole grain intake was inversely associated with hs-CRP concentrations after adjusting for age, race, BMI, illness, and antiinflammatory drug use. Consumers of between 0 and 1 serving/d of whole grains had, on average, 11.5% lower hs-CRP concentrations (P = 0.02) and consumers of $1 serving/ d had 12.3% lower hs-CRP concentrations (P = 0.02) compared with nonconsumers. Women who consumed $1 serving/ d of whole grain had a lower probability of having moderate (P = 0.008) or elevated (P = 0.001) hs-CRP according to the AHA criteria compared with nonconsumers. Given that elevated concentrations of hs-CRP have been linked to adverse reproductive outcomes and pregnancy complications, interventions targeting whole grain consumption may have the potential to improve health status among young women.
AB - In premenopausal women, elevated C-reactive protein (CRP) concentrations have been associated with an increased risk of negative reproductive outcomes. Whole grain consumption has been associated with lower CRP concentrations in older women; however, less is known about this relationship in younger women. We investigated whether whole grain intake was associated with serum high sensitivity CRP (hs-CRP) concentrations in young women. BioCycle was a prospective cohort study conducted at the University of Buffalo from 2005 to 2007, which followed 259 healthy women aged 18-44 y for ≤2 menstrual cycles. hs-CRP concentrations were measured longitudinally ≤8 times/cycle with visits standardized to menstrual cycle phase. Whole grain intake was estimated by 24-h recalls ≤4 times/cycle. Servings were defined as 16 g or 125 mL of a 100% whole grain food. Whole grain intake was inversely associated with hs-CRP concentrations after adjusting for age, race, BMI, illness, and antiinflammatory drug use. Consumers of between 0 and 1 serving/d of whole grains had, on average, 11.5% lower hs-CRP concentrations (P = 0.02) and consumers of $1 serving/ d had 12.3% lower hs-CRP concentrations (P = 0.02) compared with nonconsumers. Women who consumed $1 serving/ d of whole grain had a lower probability of having moderate (P = 0.008) or elevated (P = 0.001) hs-CRP according to the AHA criteria compared with nonconsumers. Given that elevated concentrations of hs-CRP have been linked to adverse reproductive outcomes and pregnancy complications, interventions targeting whole grain consumption may have the potential to improve health status among young women.
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U2 - 10.3945/jn.110.124164
DO - 10.3945/jn.110.124164
M3 - Article
C2 - 20668255
AN - SCOPUS:77956566004
SN - 0022-3166
VL - 140
SP - 1669
EP - 1676
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 9
ER -