Whole grains are associated with serum concentrations of high sensitivity C-reactive protein among premenopausal women

Audrey J. Gaskins, Sunni L. Mumford, Alisha J. Rovner, Cuilin Zhang, Liwei Chen, Jean Wactawski-Wende, Neil J. Perkins, Enrique F. Schisterman

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


In premenopausal women, elevated C-reactive protein (CRP) concentrations have been associated with an increased risk of negative reproductive outcomes. Whole grain consumption has been associated with lower CRP concentrations in older women; however, less is known about this relationship in younger women. We investigated whether whole grain intake was associated with serum high sensitivity CRP (hs-CRP) concentrations in young women. BioCycle was a prospective cohort study conducted at the University of Buffalo from 2005 to 2007, which followed 259 healthy women aged 18-44 y for ≤2 menstrual cycles. hs-CRP concentrations were measured longitudinally ≤8 times/cycle with visits standardized to menstrual cycle phase. Whole grain intake was estimated by 24-h recalls ≤4 times/cycle. Servings were defined as 16 g or 125 mL of a 100% whole grain food. Whole grain intake was inversely associated with hs-CRP concentrations after adjusting for age, race, BMI, illness, and antiinflammatory drug use. Consumers of between 0 and 1 serving/d of whole grains had, on average, 11.5% lower hs-CRP concentrations (P = 0.02) and consumers of $1 serving/ d had 12.3% lower hs-CRP concentrations (P = 0.02) compared with nonconsumers. Women who consumed $1 serving/ d of whole grain had a lower probability of having moderate (P = 0.008) or elevated (P = 0.001) hs-CRP according to the AHA criteria compared with nonconsumers. Given that elevated concentrations of hs-CRP have been linked to adverse reproductive outcomes and pregnancy complications, interventions targeting whole grain consumption may have the potential to improve health status among young women.

Original languageEnglish (US)
Pages (from-to)1669-1676
Number of pages8
JournalJournal of Nutrition
Issue number9
StatePublished - Sep 2010
Externally publishedYes

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Medicine (miscellaneous)


Dive into the research topics of 'Whole grains are associated with serum concentrations of high sensitivity C-reactive protein among premenopausal women'. Together they form a unique fingerprint.

Cite this