Whole-Body MRI in Musculoskeletal Oncology: A Comprehensive Review with Recommendations

Isabela A.N. Cruz, Laura M. Fayad, Shivani Ahlawat, Henrique M. Lederman, Marcelo A.C. Nico, Alípio G. Ormond Filho, Júlio Brandão Guimarães

Research output: Contribution to journalReview articlepeer-review


Whole-body (WB) MRI has emerged as an attractive method for oncologic evaluation, potentially replacing conventional imaging modalities and providing a one-step wide-coverage assessment of both the skeleton and soft tissues. In addition to providing anatomic information, WB MRI may also yield a functional analysis with the inclusion of diffusion-weighted imaging (DWI). DWI translates microstructural changes, resulting in an excellent alternative to fluorodeoxyglucose PET/CT. WB MRI (with DWI) offers comparable accuracy to PET/CT and has the advantage of avoiding ionizing radiation. Technological advances and the development of faster protocols have prompted greater accessibility of WB MRI, with growing applications in routine practice for the diagnosis, staging, and follow-up of cancer. This review discusses the technical considerations, clinical applications, and accuracy of WB MRI in musculoskeletal oncology.

Original languageEnglish (US)
Article numbere220107
JournalRadiology: Imaging Cancer
Issue number3
StatePublished - May 2023


  • Bone Marrow
  • Extremities
  • MR Imaging
  • Musculoskel-etal Imaging
  • Oncology
  • Pediatrics
  • Skeletal-Appendicular
  • Skeletal-Axial
  • Soft Tissues/Skin

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

Cite this