White matter grade and ventricular volume on brain MRI as markers of longevity in the cardiovascular health study

Lewis H. Kuller; Alice M. Arnold; W. T. Longstreth; Teri A. Manolio; Daniel H. O'Leary; Gregory L. Burke; Linda P. Fried; Anne B. Newman

doi:10.1016/j.neurobiolaging.2006.06.010

White matter grade and ventricular volume on brain MRI as markers of longevity in the cardiovascular health study

Lewis H. Kuller, Alice M. Arnold, W. T. Longstreth, Teri A. Manolio, Daniel H. O'Leary, Gregory L. Burke, Linda P. Fried, Anne B. Newman

School of Medicine

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

High white matter grade (WMG) on magnetic resonance imaging (MRI) is a risk factor for dementia, stroke and disability. Higher ventricular size is a marker of brain "atrophy." In the Cardiovascular Health Study (CHS) (n = 3245) mean age 75 years, 50% black and 40% men, we evaluated WM and ventricular grade (VG), total, cardiovascular and noncardiovascular mortality and longevity before and after adjusting for numerous determinants of longevity over an approximate 10-12 years of follow-up. A low WMG and VG was a marker for low total, cardiovascular and noncardiovascular mortality and for increased longevity over 10+ years of follow-up. We estimated that a 75-year-old with WMG below median would have about a 5-6 years greater longevity and for VG about 3 years, than above the median even after adjustment for numerous risk factors. Low WMG and VG on MRI is a powerful determinant of long-term survival among older individuals.

Original language	English (US)
Pages (from-to)	1307-1315
Number of pages	9
Journal	Neurobiology of aging
Volume	28
Issue number	9
DOIs	https://doi.org/10.1016/j.neurobiolaging.2006.06.010
State	Published - Sep 2007

Keywords

Aging
Cardiovascular disease
MRI
Survival
Ventricular size
White matter

ASJC Scopus subject areas

Neuroscience(all)
Aging
Developmental Biology
Clinical Neurology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2006.06.010

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title = "White matter grade and ventricular volume on brain MRI as markers of longevity in the cardiovascular health study",

abstract = "High white matter grade (WMG) on magnetic resonance imaging (MRI) is a risk factor for dementia, stroke and disability. Higher ventricular size is a marker of brain {"}atrophy.{"} In the Cardiovascular Health Study (CHS) (n = 3245) mean age 75 years, 50% black and 40% men, we evaluated WM and ventricular grade (VG), total, cardiovascular and noncardiovascular mortality and longevity before and after adjusting for numerous determinants of longevity over an approximate 10-12 years of follow-up. A low WMG and VG was a marker for low total, cardiovascular and noncardiovascular mortality and for increased longevity over 10+ years of follow-up. We estimated that a 75-year-old with WMG below median would have about a 5-6 years greater longevity and for VG about 3 years, than above the median even after adjustment for numerous risk factors. Low WMG and VG on MRI is a powerful determinant of long-term survival among older individuals.",

keywords = "Aging, Cardiovascular disease, MRI, Survival, Ventricular size, White matter",

author = "Kuller, {Lewis H.} and Arnold, {Alice M.} and Longstreth, {W. T.} and Manolio, {Teri A.} and O'Leary, {Daniel H.} and Burke, {Gregory L.} and Fried, {Linda P.} and Newman, {Anne B.}",

note = "Funding Information: The research reported in this article was supported by contracts N01-85079 through N01-HC-85086, N01-HC-15129 and N01-HC-15103 from the National Heart, Lung, and Blood Institute. For a full list of participating CHS investigators and institutions, see “About CHS: Principal Investigators and Study Sites” at http://www.chs-nhlbi.org . ",

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doi = "10.1016/j.neurobiolaging.2006.06.010",

language = "English (US)",

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T1 - White matter grade and ventricular volume on brain MRI as markers of longevity in the cardiovascular health study

AU - Kuller, Lewis H.

AU - Arnold, Alice M.

AU - Longstreth, W. T.

AU - Manolio, Teri A.

AU - O'Leary, Daniel H.

AU - Burke, Gregory L.

AU - Fried, Linda P.

AU - Newman, Anne B.

N1 - Funding Information: The research reported in this article was supported by contracts N01-85079 through N01-HC-85086, N01-HC-15129 and N01-HC-15103 from the National Heart, Lung, and Blood Institute. For a full list of participating CHS investigators and institutions, see “About CHS: Principal Investigators and Study Sites” at http://www.chs-nhlbi.org .

PY - 2007/9

Y1 - 2007/9

N2 - High white matter grade (WMG) on magnetic resonance imaging (MRI) is a risk factor for dementia, stroke and disability. Higher ventricular size is a marker of brain "atrophy." In the Cardiovascular Health Study (CHS) (n = 3245) mean age 75 years, 50% black and 40% men, we evaluated WM and ventricular grade (VG), total, cardiovascular and noncardiovascular mortality and longevity before and after adjusting for numerous determinants of longevity over an approximate 10-12 years of follow-up. A low WMG and VG was a marker for low total, cardiovascular and noncardiovascular mortality and for increased longevity over 10+ years of follow-up. We estimated that a 75-year-old with WMG below median would have about a 5-6 years greater longevity and for VG about 3 years, than above the median even after adjustment for numerous risk factors. Low WMG and VG on MRI is a powerful determinant of long-term survival among older individuals.

AB - High white matter grade (WMG) on magnetic resonance imaging (MRI) is a risk factor for dementia, stroke and disability. Higher ventricular size is a marker of brain "atrophy." In the Cardiovascular Health Study (CHS) (n = 3245) mean age 75 years, 50% black and 40% men, we evaluated WM and ventricular grade (VG), total, cardiovascular and noncardiovascular mortality and longevity before and after adjusting for numerous determinants of longevity over an approximate 10-12 years of follow-up. A low WMG and VG was a marker for low total, cardiovascular and noncardiovascular mortality and for increased longevity over 10+ years of follow-up. We estimated that a 75-year-old with WMG below median would have about a 5-6 years greater longevity and for VG about 3 years, than above the median even after adjustment for numerous risk factors. Low WMG and VG on MRI is a powerful determinant of long-term survival among older individuals.

KW - Aging

KW - Cardiovascular disease

KW - MRI

KW - Survival

KW - Ventricular size

KW - White matter

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White matter grade and ventricular volume on brain MRI as markers of longevity in the cardiovascular health study

Abstract

Keywords

ASJC Scopus subject areas

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