White matter development in adolescence: Diffusion tensor imaging and meta-analytic results

Bart D. Peters, Philip R. Szeszko, Joaquim Radua, Toshikazu Ikuta, Patricia Gruner, Pamela Derosse, Jian Ping Zhang, Antonio Giorgio, Deqiang Qiu, Susan F. Tapert, Jens Brauer, Miya R. Asato, P. L. Khong, Anthony C. James, Juan A. Gallego, Anil K. Malhotra

Research output: Contribution to journalArticlepeer-review


BackgroundIn light of the evidence for brain white matter (WM) abnormalities in schizophrenia, study of normal WM maturation in adolescence may provide critical insights relevant to the neurodevelopment of the disorder. Voxel-wise diffusion tensor imaging (DTI) studies have consistently demonstrated increases in fractional anisotropy (FA), a putative measure of WM integrity, from childhood into adolescence. However, the WM tracts that show FA increases have been variable across studies. Here, we aimed to assess which WM tracts show the most pronounced changes across adolescence.MethodsDTI was performed in 78 healthy subjects aged 8-21 years, and voxel-wise analysis conducted using tract-based spatial statistics (TBSS). In addition, we performed the first meta-analysis of TBSS studies on WM development in adolescence.ResultsIn our sample, we observed bilateral increases in FA with age, which were most significant in the left superior longitudinal fasciculus (SLF), inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and anterior thalamic radiation. These findings were confirmed by the meta-analysis, and FA increase in the bilateral SLF was the most consistent finding across studies. Moreover, in our sample, FA of the bilateral SLF showed a positive association with verbal working memory performance and partially mediated increases in verbal fluency as a function of increasing age.ConclusionsThese data highlight increasing connectivity in the SLF during adolescence. In light of evidence for compromised SLF integrity in high-risk and first-episode patients, these data suggest that abnormal maturation of the SLF during adolescence may be a key target in the neurodevelopment of schizophrenia.

Original languageEnglish (US)
Pages (from-to)1308-1317
Number of pages10
JournalSchizophrenia bulletin
Issue number6
StatePublished - Nov 2012
Externally publishedYes


  • adolescence
  • development
  • diffusion tensor imaging
  • superior longitudinal fasciculus
  • verbal fluency
  • working memory

ASJC Scopus subject areas

  • Psychiatry and Mental health


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