@article{10ab6c9dc9f5491294d84f68317bfdac,
title = "Which Way Do We Go? Complex Interactions in Atopic Dermatitis Pathogenesis",
abstract = "Atopic dermatitis (AD) is a common, chronic, inflammatory skin condition characterized by recurrent and pruritic skin eruptions. Multiple factors contribute to the pathogenesis of AD, including skin barrier dysfunction, microbial dysbiosis, and immune dysregulation. Interactions among these factors form a complex, multidirectional network that can reinforce atopic skin disease but can also be ameliorated by targeted therapies. This review summarizes the complex interactions among contributing factors in AD and the implications on disease development and therapeutic interventions.",
author = "Patrick, {Garrett J.} and Archer, {Nathan K.} and Miller, {Lloyd S.}",
note = "Funding Information: LSM is a full-time employee at Janssen Research and Development and may own Johnson & Johnson stock and stock options. LSM has received grant support from AstraZeneca, MedImmune (a subsidiary of AstraZeneca), Pfizer, Boehringer Ingelheim, Regeneron Pharmaceuticals, and Moderna Therapeutics; is a shareholder of Noveome Biotherapeutics; was a paid consultant for Almirall and Janssen Research and Development; and was on the scientific advisory board of Integrated Biotherapeutics, which are all developing therapeutics against infections (including Staphylococcus aureus and other pathogens) and/or inflammatory conditions. NKA has received grant support from Pfizer. Funding Information: This work was funded in part by grants R01AR073665 (LSM and NKA), R01AR069502 (LSM and NKA) and R13AR009431-55 (Principal Investigator: Molly F. Kulesz-Martin) from the U.S. National Institutes of Health . Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2021",
month = feb,
doi = "10.1016/j.jid.2020.07.006",
language = "English (US)",
volume = "141",
pages = "274--284",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "Nature Publishing Group",
number = "2",
}