Which Way Do We Go? Complex Interactions in Atopic Dermatitis Pathogenesis

Garrett J. Patrick; Nathan K. Archer; Lloyd S. Miller

doi:10.1016/j.jid.2020.07.006

Which Way Do We Go? Complex Interactions in Atopic Dermatitis Pathogenesis

Garrett J. Patrick, Nathan K. Archer, Lloyd S. Miller

School of Medicine

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Atopic dermatitis (AD) is a common, chronic, inflammatory skin condition characterized by recurrent and pruritic skin eruptions. Multiple factors contribute to the pathogenesis of AD, including skin barrier dysfunction, microbial dysbiosis, and immune dysregulation. Interactions among these factors form a complex, multidirectional network that can reinforce atopic skin disease but can also be ameliorated by targeted therapies. This review summarizes the complex interactions among contributing factors in AD and the implications on disease development and therapeutic interventions.

Original language	English (US)
Pages (from-to)	274-284
Number of pages	11
Journal	Journal of Investigative Dermatology
Volume	141
Issue number	2
DOIs	https://doi.org/10.1016/j.jid.2020.07.006
State	Published - Feb 2021

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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10.1016/j.jid.2020.07.006

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title = "Which Way Do We Go? Complex Interactions in Atopic Dermatitis Pathogenesis",

abstract = "Atopic dermatitis (AD) is a common, chronic, inflammatory skin condition characterized by recurrent and pruritic skin eruptions. Multiple factors contribute to the pathogenesis of AD, including skin barrier dysfunction, microbial dysbiosis, and immune dysregulation. Interactions among these factors form a complex, multidirectional network that can reinforce atopic skin disease but can also be ameliorated by targeted therapies. This review summarizes the complex interactions among contributing factors in AD and the implications on disease development and therapeutic interventions.",

author = "Patrick, {Garrett J.} and Archer, {Nathan K.} and Miller, {Lloyd S.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

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doi = "10.1016/j.jid.2020.07.006",

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AU - Patrick, Garrett J.

AU - Archer, Nathan K.

AU - Miller, Lloyd S.

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Y1 - 2021/2

N2 - Atopic dermatitis (AD) is a common, chronic, inflammatory skin condition characterized by recurrent and pruritic skin eruptions. Multiple factors contribute to the pathogenesis of AD, including skin barrier dysfunction, microbial dysbiosis, and immune dysregulation. Interactions among these factors form a complex, multidirectional network that can reinforce atopic skin disease but can also be ameliorated by targeted therapies. This review summarizes the complex interactions among contributing factors in AD and the implications on disease development and therapeutic interventions.

AB - Atopic dermatitis (AD) is a common, chronic, inflammatory skin condition characterized by recurrent and pruritic skin eruptions. Multiple factors contribute to the pathogenesis of AD, including skin barrier dysfunction, microbial dysbiosis, and immune dysregulation. Interactions among these factors form a complex, multidirectional network that can reinforce atopic skin disease but can also be ameliorated by targeted therapies. This review summarizes the complex interactions among contributing factors in AD and the implications on disease development and therapeutic interventions.

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AN - SCOPUS:85090837023

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JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 2

ER -

Which Way Do We Go? Complex Interactions in Atopic Dermatitis Pathogenesis

Abstract

ASJC Scopus subject areas

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