Wheat gluten challenge in schizophrenic patients

S. G. Potkin, D. Weinberger, J. Kleinman, H. Nasrallah, D. Luchins, L. Bigelow, M. Linnoila, S. H. Fischer, T. D. Bjornsson, J. Carman, J. C. Gillin, R. J. Wyatt

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Eight chronic schizophrenic patients were maintained on a diet free of gluten, cereal grains, and milk (CM-F diet) and challanged in a double-blind manner with dietary wheat gluten and placebo. While on the CM-F diet, each patient received a daily challenge of 30 g of gluten for 5 weeks and a placebo challenge for 8 weeks. No deterioration in clinical status as measured by the BPRS was noted on gluten challenge. Serum α1 acid glycoprotein measurement demonstrated no evidence of inflammatory response to gluten challenge. The data suggest that sensitivity to dietary gluten is not characteristic of young chronic schizophrenic patients.

Original languageEnglish (US)
Pages (from-to)1208-1211
Number of pages4
JournalUnknown Journal
Issue number9
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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