What's in a name? eNOS and anaphylactic shock

Charles J. Lowenstein, Thomas Michel

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


In this issue of the JCI, a study by Cauwels and colleagues suggests a central role for eNOS, the endothelial isoform of nitric oxide synthase, as a mediator of anaphylaxis (see the related article beginning on page 2244). Why is an enzyme originally described as a physiological mediator of vascular homeostasis implicated in the spectacular vascular collapse that is characteristic of anaphylaxis? And is the eNOS involved in anaphylaxis necessarily exerting its effect solely in the vascular endothelium, or might this "endothelial enzyme" actually be playing a more fundamental role in an entirely different tissue? After all, what's in a name?

Original languageEnglish (US)
Pages (from-to)2075-2078
Number of pages4
JournalJournal of Clinical Investigation
Issue number8
StatePublished - Aug 1 2006

ASJC Scopus subject areas

  • General Medicine


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