What do we need to do to cure HIV infection.

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Finding a cure for HIV infection requires methods to stop ongoing viral replication, to identify all reservoirs in which nonreplicating HIV persists, and to eliminate each of these reservoirs. Current antiretroviral therapy largely stops ongoing viral replication. This is a reflection of the extremely high antiviral activity of some classes of antiretroviral drugs as revealed in a novel index, the inhibitory potential, which incorporates the slope parameter of the dose-response curve. This index may aid in the rational selection of fully suppressive therapy. At least 2 stable reservoirs of latently infected cells have been identified, and attempts are under way to identify compounds that selectively reactivate latent HIV and allow elimination of these reservoirs. This article summarizes a presentation made by Robert F. Siliciano, MD, PhD, at the International AIDS Society-USA continuing medical education program held in Atlanta in March 2010.

Original languageEnglish (US)
Pages (from-to)104-108
Number of pages5
JournalTopics in HIV medicine : a publication of the International AIDS Society, USA
Issue number3
StatePublished - Jan 1 2010

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'What do we need to do to cure HIV infection.'. Together they form a unique fingerprint.

Cite this