What are relevant assays for refractoriness?

George K. Christophides, Louis C. Gouagna, Marcelo Jacobs-Lorena, Anthony A. James, Kenneth E. Olson

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


The engineering and testing of genes that result in refractory phenotypes are important components of the continuing effort towards the use of population replacement strategies for vector control. Both 'endogenous' and 'synthetic' refractory phenotypes are being considered. Additional research is required to determine the prevalence of such phenotypes in the various vector-pathogen combinations, and the threshold levels of activity of genes conferring transmission blocking, as well as to develop efficient methods for the evaluation of their entire spectrum of biological effects.

Original languageEnglish (US)
Title of host publicationBridging Laboratory and Field Research for Genetic Control of Disease Vectors
PublisherSpringer Netherlands
Number of pages6
ISBN (Print)9781402038006
StatePublished - 2006


  • Immunity
  • Melanization
  • RNA interference
  • Refractoriness
  • SM1

ASJC Scopus subject areas

  • General Medicine


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