Wernicke's encephalopathy: Beyond alcoholism

Robin K. Wilson, Ralph W. Kuncl, Andrea M. Corse

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Background: A 17-year-old pregnant woman presented to hospital at 19 weeks' gestation with an 8-week history of hyperemesis gravidarum, 16.8 kg of weight loss, and new-onset weakness, dizziness and blurred vision. Examination of the patient showed confusion, papilledema, ophthalmoparesis, nystagmus, reduced hearing and truncal ataxia. Investigations: Physical examination, abdominal ultrasound, fetal ultrasound, brain MRI, magnetic resonance angiography, magnetic resonance venography and cerebrospinal-fluid analysis. Diagnosis: Wernicke's encephalopathy, hyperemesis gravidarum and fetal loss. Management: Intravenous thiamine repletion and elimination of deficiency risk factors.

Original languageEnglish (US)
Pages (from-to)54-58
Number of pages5
JournalNature Clinical Practice Neurology
Issue number1
StatePublished - Jan 1 2006


  • Hyperemesis gravidarum
  • MRI paraventricular hyperintensities
  • Thiamine deficiency
  • Wernick's encephalopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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