TY - JOUR
T1 - Weight loss decreases follicle stimulating hormone in overweight postmenopausal women
AU - Kim, Catherine
AU - Randolph, John F.
AU - Golden, Sherita H.
AU - Labrie, Fernand
AU - Kong, Shengchun
AU - Nan, Bin
AU - Barrett-Connor, Elizabeth
N1 - Publisher Copyright:
© 2014 The Obesity Society.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Objectives To examine the impact of a weight loss intervention upon follicle stimulating hormone (FSH) levels in postmenopause. Methods Participants were postmenopausal, overweight, glucose-intolerant women not using exogenous estrogen (n-=-382) in the Diabetes Prevention Program. Women were randomized to intensive lifestyle change (ILS) with the goals of weight reduction of at least 7% of initial weight and 150 min per week of moderate-intensity exercise, metformin 850 mg twice a day, or placebo administered twice a day. Results Randomization to ILS led to small increases in FSH between baseline and 1-year follow-up vs. placebo (2.3 IU/l vs. -0.81 IU/l, P < 0.01). Increases in FSH were correlated with decreases in weight (r-=-0.165, P < 0.01) and estradiol (E2) (r-=-0.464, P < 0.0001) after adjustment for age, race/ethnicity, and randomization arm. Changes in FSH were still significantly associated with changes in weight even after adjustment for E2 levels. Metformin users had reductions in weight but non-significant changes in FSH and E2 levels vs. placebo. Conclusions Weight loss leads to small increases in FSH among overweight, postmenopausal women, potentially through pathways mediated by endogenous estrogen as well as other pathways.
AB - Objectives To examine the impact of a weight loss intervention upon follicle stimulating hormone (FSH) levels in postmenopause. Methods Participants were postmenopausal, overweight, glucose-intolerant women not using exogenous estrogen (n-=-382) in the Diabetes Prevention Program. Women were randomized to intensive lifestyle change (ILS) with the goals of weight reduction of at least 7% of initial weight and 150 min per week of moderate-intensity exercise, metformin 850 mg twice a day, or placebo administered twice a day. Results Randomization to ILS led to small increases in FSH between baseline and 1-year follow-up vs. placebo (2.3 IU/l vs. -0.81 IU/l, P < 0.01). Increases in FSH were correlated with decreases in weight (r-=-0.165, P < 0.01) and estradiol (E2) (r-=-0.464, P < 0.0001) after adjustment for age, race/ethnicity, and randomization arm. Changes in FSH were still significantly associated with changes in weight even after adjustment for E2 levels. Metformin users had reductions in weight but non-significant changes in FSH and E2 levels vs. placebo. Conclusions Weight loss leads to small increases in FSH among overweight, postmenopausal women, potentially through pathways mediated by endogenous estrogen as well as other pathways.
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U2 - 10.1002/oby.20917
DO - 10.1002/oby.20917
M3 - Article
C2 - 25294746
AN - SCOPUS:84928269905
SN - 1930-7381
VL - 23
SP - 228
EP - 233
JO - Obesity
JF - Obesity
IS - 1
ER -