Weight gain and maternal behavior in CCK1 deficient rats

Mariana Schroeder; Orna Zagoory-Sharon; Yael Lavi-Avnon; Timothy H. Moran; Aron Weller

doi:10.1016/j.physbeh.2006.07.008

Weight gain and maternal behavior in CCK₁ deficient rats

Mariana Schroeder, Orna Zagoory-Sharon, Yael Lavi-Avnon, Timothy H. Moran, Aron Weller

School of Medicine

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The OLETF rat model of obesity has been extensively studied as an adult model of hyperphagia-induced obesity. In order to better understand the early circumstances that make OLETF pups obese, we investigated body weight from postnatal day (PND) 1 and examined diurnal maternal behavior over the first three postpartum weeks by undisturbed observations. Male and female OLETF rats weighed significantly more than LETO controls from PND 1 until adulthood. Differences in nursing behavior were observed only in the third postnatal week: OLETF dams exhibited more frequent nursing. OLETF dams displayed less self-directed behaviors and activity, over the entire postpartum period examined. Taken together, these data demonstrate that OLETF males and females are heavier from birth and suggest that maternal factors may contribute to weight differences between the strains.

Original language	English (US)
Pages (from-to)	402-409
Number of pages	8
Journal	Physiology and Behavior
Volume	89
Issue number	3
DOIs	https://doi.org/10.1016/j.physbeh.2006.07.008
State	Published - Oct 30 2006

Keywords

CCK
Maternal care
Nursing
Obesity
Ontogeny
Weight gain

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

Access to Document

10.1016/j.physbeh.2006.07.008

Cite this

@article{39376e11f2684a39a667f7e87dec8196,

title = "Weight gain and maternal behavior in CCK1 deficient rats",

abstract = "The OLETF rat model of obesity has been extensively studied as an adult model of hyperphagia-induced obesity. In order to better understand the early circumstances that make OLETF pups obese, we investigated body weight from postnatal day (PND) 1 and examined diurnal maternal behavior over the first three postpartum weeks by undisturbed observations. Male and female OLETF rats weighed significantly more than LETO controls from PND 1 until adulthood. Differences in nursing behavior were observed only in the third postnatal week: OLETF dams exhibited more frequent nursing. OLETF dams displayed less self-directed behaviors and activity, over the entire postpartum period examined. Taken together, these data demonstrate that OLETF males and females are heavier from birth and suggest that maternal factors may contribute to weight differences between the strains.",

keywords = "CCK, Maternal care, Nursing, Obesity, Ontogeny, Weight gain",

author = "Mariana Schroeder and Orna Zagoory-Sharon and Yael Lavi-Avnon and Moran, {Timothy H.} and Aron Weller",

note = "Funding Information: The authors thank Dr. Kawano of Otsuka Tokushima Research Institute for the OLETF and LETO rats. OZS was partially supported by the Gonda Brain Research Center, Bar-Ilan University. This work was supported by a grant from the US–Israel Binational Research Foundation to AW and THM. Research in the Developmental Psychobiology lab is partially supported by the Paula Rich Center, Bar-Ilan University. ",

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AU - Zagoory-Sharon, Orna

AU - Lavi-Avnon, Yael

AU - Moran, Timothy H.

AU - Weller, Aron

N1 - Funding Information: The authors thank Dr. Kawano of Otsuka Tokushima Research Institute for the OLETF and LETO rats. OZS was partially supported by the Gonda Brain Research Center, Bar-Ilan University. This work was supported by a grant from the US–Israel Binational Research Foundation to AW and THM. Research in the Developmental Psychobiology lab is partially supported by the Paula Rich Center, Bar-Ilan University.

PY - 2006/10/30

Y1 - 2006/10/30

N2 - The OLETF rat model of obesity has been extensively studied as an adult model of hyperphagia-induced obesity. In order to better understand the early circumstances that make OLETF pups obese, we investigated body weight from postnatal day (PND) 1 and examined diurnal maternal behavior over the first three postpartum weeks by undisturbed observations. Male and female OLETF rats weighed significantly more than LETO controls from PND 1 until adulthood. Differences in nursing behavior were observed only in the third postnatal week: OLETF dams exhibited more frequent nursing. OLETF dams displayed less self-directed behaviors and activity, over the entire postpartum period examined. Taken together, these data demonstrate that OLETF males and females are heavier from birth and suggest that maternal factors may contribute to weight differences between the strains.

AB - The OLETF rat model of obesity has been extensively studied as an adult model of hyperphagia-induced obesity. In order to better understand the early circumstances that make OLETF pups obese, we investigated body weight from postnatal day (PND) 1 and examined diurnal maternal behavior over the first three postpartum weeks by undisturbed observations. Male and female OLETF rats weighed significantly more than LETO controls from PND 1 until adulthood. Differences in nursing behavior were observed only in the third postnatal week: OLETF dams exhibited more frequent nursing. OLETF dams displayed less self-directed behaviors and activity, over the entire postpartum period examined. Taken together, these data demonstrate that OLETF males and females are heavier from birth and suggest that maternal factors may contribute to weight differences between the strains.

KW - CCK

KW - Maternal care

KW - Nursing

KW - Obesity

KW - Ontogeny

KW - Weight gain

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