Abstract
Weight changes, neuropsychiatric symptoms (NPS), and cognitive decline often coincide in Alzheimer's disease (AD) and frontotemporal dementia (FTD); however, the direction of their relationship remains unclear. This study aims to clarify the connection between weight changes, NPS, and cognition in AD and FTD. We found that cognitive decline was associated with decreased body mass index (BMI) in AD, while BMI gain was associated with increased conversion to FTD. Elevated NPS were associated with decreased BMI in AD and increased BMI in FTD. Identifying early changes in NPS and BMI may facilitate the detection of cognitive decline, providing an opportunity for early intervention.
Original language | English (US) |
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Pages (from-to) | 767-774 |
Number of pages | 8 |
Journal | Journal of Alzheimer's Disease Reports |
Volume | 7 |
Issue number | 1 |
DOIs | |
State | Published - 2023 |
Keywords
- Alzheimer's disease
- body mass index
- cognition
- cognitive decline
- frontotemporal dementia
- neuropsychiatric symptoms
- weight changes
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Psychiatry and Mental health
- Clinical Psychology
- General Neuroscience