Weight Change and Neuropsychiatric Symptoms in Alzheimer's Disease and Frontotemporal Dementia: Associations with Cognitive Decline

Research output: Contribution to journalArticlepeer-review

Abstract

Weight changes, neuropsychiatric symptoms (NPS), and cognitive decline often coincide in Alzheimer's disease (AD) and frontotemporal dementia (FTD); however, the direction of their relationship remains unclear. This study aims to clarify the connection between weight changes, NPS, and cognition in AD and FTD. We found that cognitive decline was associated with decreased body mass index (BMI) in AD, while BMI gain was associated with increased conversion to FTD. Elevated NPS were associated with decreased BMI in AD and increased BMI in FTD. Identifying early changes in NPS and BMI may facilitate the detection of cognitive decline, providing an opportunity for early intervention.

Original languageEnglish (US)
Pages (from-to)767-774
Number of pages8
JournalJournal of Alzheimer's Disease Reports
Volume7
Issue number1
DOIs
StatePublished - 2023

Keywords

  • Alzheimer's disease
  • body mass index
  • cognition
  • cognitive decline
  • frontotemporal dementia
  • neuropsychiatric symptoms
  • weight changes

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Clinical Psychology
  • General Neuroscience

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