WE‐D‐330A‐08: The Small‐Animal Radiation Research Platform (SARRP): Commissioning a 225 KVp “small‐Field” X‐Ray Source for Monte Carlo‐Based Treatment Planning

E. Tryggestad; E. Armour; H. Deng; E. Ford; J. Huang; I. Iordachita; P. Kazanzides; C. Kennedy; T. Mcnutt; F. Verhaegen; J. Wong

doi:10.1118/1.2241749

WE‐D‐330A‐08: The Small‐Animal Radiation Research Platform (SARRP): Commissioning a 225 KVp “small‐Field” X‐Ray Source for Monte Carlo‐Based Treatment Planning

E. Tryggestad, E. Armour, H. Deng, E. Ford, J. Huang, I. Iordachita, P. Kazanzides, C. Kennedy, T. Mcnutt, F. Verhaegen, J. Wong

School of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Purpose: To characterize the dosimetry of a small‐field 225 kVp x‐ray source and demonstrate the feasibility of the Pinnacle Monte Carlo Dose Computation engine (v7.9t alpha release) for treatment planning in the context of small‐animal radiation therapy. Method and Materials: The 225 kVp therapeutic x‐rays for the Small‐Animal Radiation Research Platform (SARRP) are produced by a GE 225 x‐ray tube (spot size 3 mm; Al filtration 4 mm). A simple small‐field collimation system was constructed; for commissioning purposes we machined a set of brass cutouts which define field sizes of 3×3, 5×5, 10×10, 30×30 and 60×60 mm² at the nominal SARRP source‐to‐axis distance of 33.5 cm. The x‐ray beams were characterized by irradiating Gafchromic EBT film in water. The film plane was oriented parallel to the central beam axis (z); measurements were made in the x‐z and y‐z planes for all field sizes. Dosimetric data were extracted from the films using a commercial flat‐bed document scanner. Profiles and percent depth‐dose (PDD) curves for depths from 0–9 cm (SSD = 33.5 cm) were imported into our research planning software for comparison with simulated data. Results: Preliminary simulated profiles for the 60×60 mm² cutout deviate, on average, by 1.7% and 2.8% in the high‐dose region (90% or greater) for depths of 0.5 and 3 cm, respectively. Average PDD discrepancies for depths from 0–3 cm and 3–6 cm are 4.3% and 18.4% for the 60×60 mm² cutout, respectively, and 6.6% and 29.2% for the 5×5 mm² cutout. Conclusion: These encouraging results identify the feasibility of using this planning system. Pinnacle supports the finer resolution required for modeling the small fields. Future development will involve incorporation of a measured photon energy spectrum. For purposes of comparison and validation, we will also incorporate an independently‐generated photon phase‐space file for the simulated x‐rays.

Original language	English (US)
Pages (from-to)	2241
Number of pages	1
Journal	Medical physics
Volume	33
Issue number	6
DOIs	https://doi.org/10.1118/1.2241749
State	Published - Jun 2006

ASJC Scopus subject areas

Biophysics
Radiology Nuclear Medicine and imaging

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Tryggestad, E., Armour, E., Deng, H., Ford, E., Huang, J., Iordachita, I., Kazanzides, P., Kennedy, C., Mcnutt, T., Verhaegen, F., & Wong, J. (2006). WE‐D‐330A‐08: The Small‐Animal Radiation Research Platform (SARRP): Commissioning a 225 KVp “small‐Field” X‐Ray Source for Monte Carlo‐Based Treatment Planning. Medical physics, 33(6), 2241. https://doi.org/10.1118/1.2241749

Tryggestad, E, Armour, E, Deng, H, Ford, E, Huang, J, Iordachita, I, Kazanzides, P, Kennedy, C, Mcnutt, T, Verhaegen, F & Wong, J 2006, 'WE‐D‐330A‐08: The Small‐Animal Radiation Research Platform (SARRP): Commissioning a 225 KVp “small‐Field” X‐Ray Source for Monte Carlo‐Based Treatment Planning', Medical physics, vol. 33, no. 6, pp. 2241. https://doi.org/10.1118/1.2241749

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title = "WE‐D‐330A‐08: The Small‐Animal Radiation Research Platform (SARRP): Commissioning a 225 KVp “small‐Field” X‐Ray Source for Monte Carlo‐Based Treatment Planning",

abstract = "Purpose: To characterize the dosimetry of a small‐field 225 kVp x‐ray source and demonstrate the feasibility of the Pinnacle Monte Carlo Dose Computation engine (v7.9t alpha release) for treatment planning in the context of small‐animal radiation therapy. Method and Materials: The 225 kVp therapeutic x‐rays for the Small‐Animal Radiation Research Platform (SARRP) are produced by a GE 225 x‐ray tube (spot size 3 mm; Al filtration 4 mm). A simple small‐field collimation system was constructed; for commissioning purposes we machined a set of brass cutouts which define field sizes of 3×3, 5×5, 10×10, 30×30 and 60×60 mm2 at the nominal SARRP source‐to‐axis distance of 33.5 cm. The x‐ray beams were characterized by irradiating Gafchromic EBT film in water. The film plane was oriented parallel to the central beam axis (z); measurements were made in the x‐z and y‐z planes for all field sizes. Dosimetric data were extracted from the films using a commercial flat‐bed document scanner. Profiles and percent depth‐dose (PDD) curves for depths from 0–9 cm (SSD = 33.5 cm) were imported into our research planning software for comparison with simulated data. Results: Preliminary simulated profiles for the 60×60 mm2 cutout deviate, on average, by 1.7% and 2.8% in the high‐dose region (90% or greater) for depths of 0.5 and 3 cm, respectively. Average PDD discrepancies for depths from 0–3 cm and 3–6 cm are 4.3% and 18.4% for the 60×60 mm2 cutout, respectively, and 6.6% and 29.2% for the 5×5 mm2 cutout. Conclusion: These encouraging results identify the feasibility of using this planning system. Pinnacle supports the finer resolution required for modeling the small fields. Future development will involve incorporation of a measured photon energy spectrum. For purposes of comparison and validation, we will also incorporate an independently‐generated photon phase‐space file for the simulated x‐rays.",

author = "E. Tryggestad and E. Armour and H. Deng and E. Ford and J. Huang and I. Iordachita and P. Kazanzides and C. Kennedy and T. Mcnutt and F. Verhaegen and J. Wong",

year = "2006",

month = jun,

doi = "10.1118/1.2241749",

language = "English (US)",

volume = "33",

pages = "2241",

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T2 - The Small‐Animal Radiation Research Platform (SARRP): Commissioning a 225 KVp “small‐Field” X‐Ray Source for Monte Carlo‐Based Treatment Planning

AU - Tryggestad, E.

AU - Armour, E.

AU - Deng, H.

AU - Ford, E.

AU - Huang, J.

AU - Iordachita, I.

AU - Kazanzides, P.

AU - Kennedy, C.

AU - Mcnutt, T.

AU - Verhaegen, F.

AU - Wong, J.

PY - 2006/6

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N2 - Purpose: To characterize the dosimetry of a small‐field 225 kVp x‐ray source and demonstrate the feasibility of the Pinnacle Monte Carlo Dose Computation engine (v7.9t alpha release) for treatment planning in the context of small‐animal radiation therapy. Method and Materials: The 225 kVp therapeutic x‐rays for the Small‐Animal Radiation Research Platform (SARRP) are produced by a GE 225 x‐ray tube (spot size 3 mm; Al filtration 4 mm). A simple small‐field collimation system was constructed; for commissioning purposes we machined a set of brass cutouts which define field sizes of 3×3, 5×5, 10×10, 30×30 and 60×60 mm2 at the nominal SARRP source‐to‐axis distance of 33.5 cm. The x‐ray beams were characterized by irradiating Gafchromic EBT film in water. The film plane was oriented parallel to the central beam axis (z); measurements were made in the x‐z and y‐z planes for all field sizes. Dosimetric data were extracted from the films using a commercial flat‐bed document scanner. Profiles and percent depth‐dose (PDD) curves for depths from 0–9 cm (SSD = 33.5 cm) were imported into our research planning software for comparison with simulated data. Results: Preliminary simulated profiles for the 60×60 mm2 cutout deviate, on average, by 1.7% and 2.8% in the high‐dose region (90% or greater) for depths of 0.5 and 3 cm, respectively. Average PDD discrepancies for depths from 0–3 cm and 3–6 cm are 4.3% and 18.4% for the 60×60 mm2 cutout, respectively, and 6.6% and 29.2% for the 5×5 mm2 cutout. Conclusion: These encouraging results identify the feasibility of using this planning system. Pinnacle supports the finer resolution required for modeling the small fields. Future development will involve incorporation of a measured photon energy spectrum. For purposes of comparison and validation, we will also incorporate an independently‐generated photon phase‐space file for the simulated x‐rays.

AB - Purpose: To characterize the dosimetry of a small‐field 225 kVp x‐ray source and demonstrate the feasibility of the Pinnacle Monte Carlo Dose Computation engine (v7.9t alpha release) for treatment planning in the context of small‐animal radiation therapy. Method and Materials: The 225 kVp therapeutic x‐rays for the Small‐Animal Radiation Research Platform (SARRP) are produced by a GE 225 x‐ray tube (spot size 3 mm; Al filtration 4 mm). A simple small‐field collimation system was constructed; for commissioning purposes we machined a set of brass cutouts which define field sizes of 3×3, 5×5, 10×10, 30×30 and 60×60 mm2 at the nominal SARRP source‐to‐axis distance of 33.5 cm. The x‐ray beams were characterized by irradiating Gafchromic EBT film in water. The film plane was oriented parallel to the central beam axis (z); measurements were made in the x‐z and y‐z planes for all field sizes. Dosimetric data were extracted from the films using a commercial flat‐bed document scanner. Profiles and percent depth‐dose (PDD) curves for depths from 0–9 cm (SSD = 33.5 cm) were imported into our research planning software for comparison with simulated data. Results: Preliminary simulated profiles for the 60×60 mm2 cutout deviate, on average, by 1.7% and 2.8% in the high‐dose region (90% or greater) for depths of 0.5 and 3 cm, respectively. Average PDD discrepancies for depths from 0–3 cm and 3–6 cm are 4.3% and 18.4% for the 60×60 mm2 cutout, respectively, and 6.6% and 29.2% for the 5×5 mm2 cutout. Conclusion: These encouraging results identify the feasibility of using this planning system. Pinnacle supports the finer resolution required for modeling the small fields. Future development will involve incorporation of a measured photon energy spectrum. For purposes of comparison and validation, we will also incorporate an independently‐generated photon phase‐space file for the simulated x‐rays.

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WE‐D‐330A‐08: The Small‐Animal Radiation Research Platform (SARRP): Commissioning a 225 KVp “small‐Field” X‐Ray Source for Monte Carlo‐Based Treatment Planning

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