Water-soluble porphyrin-phosphonate conjugates as potential photodynamic therapy photosensitizers

Yunguo Lu; Zhihang Chen; Bingqiong Yu; Kun Yan; Zaoying Li

doi:10.1142/S1088424615500789

Water-soluble porphyrin-phosphonate conjugates as potential photodynamic therapy photosensitizers

Yunguo Lu
, Zhihang Chen
, Bingqiong Yu
, Kun Yan
, Zaoying Li

School of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Two novel water-soluble porphyrin-phosphonate conjugates were synthesized and characterized. Although both conjugates showed significant potential in photodynamic therapy, the variety of their structure induced the obvious differences in the binding manner with calf thymus DNA, the cytotoxicity and the cellular sublocalization.

Original language	English (US)
Pages (from-to)	1039-1045
Number of pages	7
Journal	Journal of Porphyrins and Phthalocyanines
Volume	19
Issue number	9
DOIs	https://doi.org/10.1142/S1088424615500789
State	Published - Sep 1 2015

Keywords

DNA
photodynamic therapy
photosensitizers
porphyrin-phosphonate conjugates

ASJC Scopus subject areas

General Chemistry

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10.1142/S1088424615500789

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title = "Water-soluble porphyrin-phosphonate conjugates as potential photodynamic therapy photosensitizers",

abstract = "Two novel water-soluble porphyrin-phosphonate conjugates were synthesized and characterized. Although both conjugates showed significant potential in photodynamic therapy, the variety of their structure induced the obvious differences in the binding manner with calf thymus DNA, the cytotoxicity and the cellular sublocalization.",

keywords = "DNA, photodynamic therapy, photosensitizers, porphyrin-phosphonate conjugates",

author = "Yunguo Lu and Zhihang Chen and Bingqiong Yu and Kun Yan and Zaoying Li",

note = "Funding Information: The study was supported by National Natural Science Foundation (NNSF) of China (Grant No. 21401144) and Nature Science Foundation of Hubei Province, China (Grant No. 2013CFB236). Publisher Copyright: {\textcopyright} 2015 World Scientific Publishing Company.",

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T1 - Water-soluble porphyrin-phosphonate conjugates as potential photodynamic therapy photosensitizers

AU - Lu, Yunguo

AU - Chen, Zhihang

AU - Yu, Bingqiong

AU - Yan, Kun

AU - Li, Zaoying

N1 - Funding Information: The study was supported by National Natural Science Foundation (NNSF) of China (Grant No. 21401144) and Nature Science Foundation of Hubei Province, China (Grant No. 2013CFB236). Publisher Copyright: © 2015 World Scientific Publishing Company.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Two novel water-soluble porphyrin-phosphonate conjugates were synthesized and characterized. Although both conjugates showed significant potential in photodynamic therapy, the variety of their structure induced the obvious differences in the binding manner with calf thymus DNA, the cytotoxicity and the cellular sublocalization.

AB - Two novel water-soluble porphyrin-phosphonate conjugates were synthesized and characterized. Although both conjugates showed significant potential in photodynamic therapy, the variety of their structure induced the obvious differences in the binding manner with calf thymus DNA, the cytotoxicity and the cellular sublocalization.

KW - DNA

KW - photodynamic therapy

KW - photosensitizers

KW - porphyrin-phosphonate conjugates

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M3 - Article

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JO - Journal of Porphyrins and Phthalocyanines

JF - Journal of Porphyrins and Phthalocyanines

IS - 9

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Water-soluble porphyrin-phosphonate conjugates as potential photodynamic therapy photosensitizers

Abstract

Keywords

ASJC Scopus subject areas

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