TY - JOUR
T1 - Wasm-iCARE
T2 - a portable and privacy-preserving web module to build, validate, and apply absolute risk models
AU - Balasubramanian, Jeya Balaji
AU - Choudhury, Parichoy Pal
AU - Mukhopadhyay, Srijon
AU - Ahearn, Thomas
AU - Chatterjee, Nilanjan
AU - García-Closas, Montserrat
AU - Almeida, Jonas S.
N1 - Publisher Copyright:
© 2024 Published by Oxford University Press on behalf of the American Medical Informatics Association.
PY - 2024/7/1
Y1 - 2024/7/1
N2 - Objectives: Absolute risk models estimate an individual's future disease risk over a specified time interval. Applications utilizing server-side risk tooling, the R-based iCARE (R-iCARE), to build, validate, and apply absolute risk models, face limitations in portability and privacy due to their need for circulating user data in remote servers for operation. We overcome this by porting iCARE to the web platform. Materials and Methods: We refactored R-iCARE into a Python package (Py-iCARE) and then compiled it to WebAssembly (Wasm-iCARE) - a portable web module, which operates within the privacy of the user's device. Results: We showcase the portability and privacy of Wasm-iCARE through 2 applications: for researchers to statistically validate risk models and to deliver them to end-users. Both applications run entirely on the client side, requiring no downloads or installations, and keep user data on-device during risk calculation. Conclusions: Wasm-iCARE fosters accessible and privacy-preserving risk tools, accelerating their validation and delivery.
AB - Objectives: Absolute risk models estimate an individual's future disease risk over a specified time interval. Applications utilizing server-side risk tooling, the R-based iCARE (R-iCARE), to build, validate, and apply absolute risk models, face limitations in portability and privacy due to their need for circulating user data in remote servers for operation. We overcome this by porting iCARE to the web platform. Materials and Methods: We refactored R-iCARE into a Python package (Py-iCARE) and then compiled it to WebAssembly (Wasm-iCARE) - a portable web module, which operates within the privacy of the user's device. Results: We showcase the portability and privacy of Wasm-iCARE through 2 applications: for researchers to statistically validate risk models and to deliver them to end-users. Both applications run entirely on the client side, requiring no downloads or installations, and keep user data on-device during risk calculation. Conclusions: Wasm-iCARE fosters accessible and privacy-preserving risk tools, accelerating their validation and delivery.
KW - portable software applications
KW - preventative medicine
KW - risk analysis
KW - world wide web
UR - http://www.scopus.com/inward/record.url?scp=85198034950&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85198034950&partnerID=8YFLogxK
U2 - 10.1093/jamiaopen/ooae055
DO - 10.1093/jamiaopen/ooae055
M3 - Article
AN - SCOPUS:85198034950
SN - 2574-2531
VL - 7
JO - JAMIA Open
JF - JAMIA Open
IS - 2
M1 - ooae055
ER -