Waist-to-Height Ratio as a Predictor of C-Reactive Protein Levels

Denise Tavares Giannini, Maria Cristina Caetano Kuschnir, Cecília Lacroix de Oliveira, Moyses Szklo

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: C-reactive protein is an acute-phase protein that has been found in association with adiposity and cardiovascular disease risk. In this paper, the objective was to assess the relationship of C-reactive protein to four anthropometric measurements: body mass index, waist-to-height ratio, C index, and waist circumference. Methods: A cross-sectional random sample of the Study of Cardiovascular Risk in Adolescents (Portuguese acronym “ERICA”) was included in the study. The analysis was adjusted for the complex sampling design. Poisson regression models with robust variance were used to estimate a multivariate-adjusted prevalence rate ratio expressing the relationship of each anthropometric measure to C-reactive protein. We evaluated adolescents aged 12 to 17 years participating in the capital of Porto Alegre, Brazil. Results: In all, 778 adolescents were included (60% female, 58% aged 15–17 years). Waist-to-height ratio was found to be the strongest adiposity marker associated with C-reactive protein even after adjusting for age, sex, smoking, physical activity, and insulin resistance (prevalence rate ratio = 7.09; 95% confidence interval, 5.01–9.18; p < 0.001). Conclusions: Waist-to-height ratio is a strong predictor of C-reactive protein in adolescents in Porto Alegre, Brazil.

Original languageEnglish (US)
Pages (from-to)624-630
Number of pages7
JournalJournal of the American College of Nutrition
Issue number8
StatePublished - Nov 17 2017


  • Anthropometry
  • C-reactive protein
  • adolescent
  • cardiovascular disease
  • insulin resistance
  • obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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