Vulvar Lesions in an 8-Year-Old Girl: Cutaneous Manifestations of Multisystem Langerhans Cell Histiocytosis

Elisa M. Jorgensen; Peter P. Chen; Sarah Rutter; Julia A. Cron

doi:10.1016/j.jpag.2017.09.010

Vulvar Lesions in an 8-Year-Old Girl: Cutaneous Manifestations of Multisystem Langerhans Cell Histiocytosis

Elisa M. Jorgensen, Peter P. Chen, Sarah Rutter, Julia A. Cron

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: Langerhans cell histiocytosis (LCH) is a rare localized or systemic disease characterized by proliferation of myeloid-derived dendritic cells. Vulvar lesions might be the herald symptom of LCH and might mimic other cutaneous lesions. Prognosis varies widely on the basis of the extent and spread of disease. Case: An 8-year-old girl with a 4-month history of vulvar lesions resistant to topical steroids was referred by her pediatrician. Vulvar biopsy was diagnostic for LCH. Imaging studies revealed a left hip lesion consistent with LCH. The patient was subsequently treated for multisystem LCH with vinblastine and prednisone. Summary and Conclusion: Although rare, LCH might be diagnosed by gynecologic providers and should be included in the differential diagnosis of genital lesions. We recommend having a low threshold for performing biopsy of vulvar lesions.

Original language	English (US)
Pages (from-to)	153-155
Number of pages	3
Journal	Journal of pediatric and adolescent gynecology
Volume	31
Issue number	2
DOIs	https://doi.org/10.1016/j.jpag.2017.09.010
State	Published - Apr 2018
Externally published	Yes

Keywords

LCH
Langerhans cell histiocytosis
Vulva
Vulvar lesion

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1016/j.jpag.2017.09.010

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title = "Vulvar Lesions in an 8-Year-Old Girl: Cutaneous Manifestations of Multisystem Langerhans Cell Histiocytosis",

abstract = "Background: Langerhans cell histiocytosis (LCH) is a rare localized or systemic disease characterized by proliferation of myeloid-derived dendritic cells. Vulvar lesions might be the herald symptom of LCH and might mimic other cutaneous lesions. Prognosis varies widely on the basis of the extent and spread of disease. Case: An 8-year-old girl with a 4-month history of vulvar lesions resistant to topical steroids was referred by her pediatrician. Vulvar biopsy was diagnostic for LCH. Imaging studies revealed a left hip lesion consistent with LCH. The patient was subsequently treated for multisystem LCH with vinblastine and prednisone. Summary and Conclusion: Although rare, LCH might be diagnosed by gynecologic providers and should be included in the differential diagnosis of genital lesions. We recommend having a low threshold for performing biopsy of vulvar lesions.",

keywords = "LCH, Langerhans cell histiocytosis, Vulva, Vulvar lesion",

author = "Jorgensen, {Elisa M.} and Chen, {Peter P.} and Sarah Rutter and Cron, {Julia A.}",

note = "Publisher Copyright: {\textcopyright} 2017 North American Society for Pediatric and Adolescent Gynecology",

year = "2018",

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doi = "10.1016/j.jpag.2017.09.010",

language = "English (US)",

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journal = "Journal of pediatric and adolescent gynecology",

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T1 - Vulvar Lesions in an 8-Year-Old Girl

T2 - Cutaneous Manifestations of Multisystem Langerhans Cell Histiocytosis

AU - Jorgensen, Elisa M.

AU - Chen, Peter P.

AU - Rutter, Sarah

AU - Cron, Julia A.

PY - 2018/4

Y1 - 2018/4

N2 - Background: Langerhans cell histiocytosis (LCH) is a rare localized or systemic disease characterized by proliferation of myeloid-derived dendritic cells. Vulvar lesions might be the herald symptom of LCH and might mimic other cutaneous lesions. Prognosis varies widely on the basis of the extent and spread of disease. Case: An 8-year-old girl with a 4-month history of vulvar lesions resistant to topical steroids was referred by her pediatrician. Vulvar biopsy was diagnostic for LCH. Imaging studies revealed a left hip lesion consistent with LCH. The patient was subsequently treated for multisystem LCH with vinblastine and prednisone. Summary and Conclusion: Although rare, LCH might be diagnosed by gynecologic providers and should be included in the differential diagnosis of genital lesions. We recommend having a low threshold for performing biopsy of vulvar lesions.

AB - Background: Langerhans cell histiocytosis (LCH) is a rare localized or systemic disease characterized by proliferation of myeloid-derived dendritic cells. Vulvar lesions might be the herald symptom of LCH and might mimic other cutaneous lesions. Prognosis varies widely on the basis of the extent and spread of disease. Case: An 8-year-old girl with a 4-month history of vulvar lesions resistant to topical steroids was referred by her pediatrician. Vulvar biopsy was diagnostic for LCH. Imaging studies revealed a left hip lesion consistent with LCH. The patient was subsequently treated for multisystem LCH with vinblastine and prednisone. Summary and Conclusion: Although rare, LCH might be diagnosed by gynecologic providers and should be included in the differential diagnosis of genital lesions. We recommend having a low threshold for performing biopsy of vulvar lesions.

KW - LCH

KW - Langerhans cell histiocytosis

KW - Vulva

KW - Vulvar lesion

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Vulvar Lesions in an 8-Year-Old Girl: Cutaneous Manifestations of Multisystem Langerhans Cell Histiocytosis

Abstract

Keywords

ASJC Scopus subject areas

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