VLSI potentiostat array with oversampling gain modulation for wide-range neurotransmitter sensing

Milutin Stanaćević; Kartikeya Murari; Abhishek Rege; Gert Cauwenberghs; Nitish V. Thakor

doi:10.1109/TBCAS.2007.893176

VLSI potentiostat array with oversampling gain modulation for wide-range neurotransmitter sensing

Milutin Stanaćević, Kartikeya Murari, Abhishek Rege, Gert Cauwenberghs, Nitish V. Thakor

School of Medicine

Research output: Contribution to journal › Article › peer-review

109 Scopus citations

Abstract

A 16-channel current-measuring very large-scale integration (VLSI) sensor array system for highly sensitive electrochemical detection of electroactive neurotransmiters like dopamine and nitric-oxide is presented. Each channel embeds a current integrating potentiostat within a switched-capacitor first-order single-bit delta-sigma modulator implementing an incremental analog-to-digital converter. The duty-cycle modulation of current feedback in the delta-sigma loop together with variable oversampling ratio provide a programmable digital range selection of the input current spanning over six orders of magnitude from picoamperes to microamperes. The array offers 100-fA input current sensitivity at 3.4-μW power consumption per channel. The operation of the 3 mm × 3 mm chip fabricated in 0.5-μm CMOS technology is demonstrated with real-time multichannel acquisition of neurotransmitter concentration.

Original language	English (US)
Pages (from-to)	63-72
Number of pages	10
Journal	IEEE Transactions on Biomedical Circuits and Systems
Volume	1
Issue number	1
DOIs	https://doi.org/10.1109/TBCAS.2007.893176
State	Published - Mar 2007

Keywords

Biomedical instrumentation
Correlated double sampling
Current measurement
Micropower techniques
Potentiostat
Sigma-delta modulator
Switched-capacitor circuits

ASJC Scopus subject areas

Biomedical Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/TBCAS.2007.893176

Cite this

@article{9c8643d3a2b74ac1ac0b8957c9d677ed,

title = "VLSI potentiostat array with oversampling gain modulation for wide-range neurotransmitter sensing",

abstract = "A 16-channel current-measuring very large-scale integration (VLSI) sensor array system for highly sensitive electrochemical detection of electroactive neurotransmiters like dopamine and nitric-oxide is presented. Each channel embeds a current integrating potentiostat within a switched-capacitor first-order single-bit delta-sigma modulator implementing an incremental analog-to-digital converter. The duty-cycle modulation of current feedback in the delta-sigma loop together with variable oversampling ratio provide a programmable digital range selection of the input current spanning over six orders of magnitude from picoamperes to microamperes. The array offers 100-fA input current sensitivity at 3.4-μW power consumption per channel. The operation of the 3 mm × 3 mm chip fabricated in 0.5-μm CMOS technology is demonstrated with real-time multichannel acquisition of neurotransmitter concentration.",

keywords = "Biomedical instrumentation, Correlated double sampling, Current measurement, Micropower techniques, Potentiostat, Sigma-delta modulator, Switched-capacitor circuits",

author = "Milutin Stana{\'c}evi{\'c} and Kartikeya Murari and Abhishek Rege and Gert Cauwenberghs and Thakor, {Nitish V.}",

note = "Funding Information: Manuscript received December 16, 2006; revised January 16, 2007. This work was supported in part by the National Institutes of Health, National Institute of Aging, National Science Foundation, Defense Advanced Research Projects Agency, and the Whitaker Foundation. This paper was recommended by Editor-in-Chief T. S. Lande.",

year = "2007",

month = mar,

doi = "10.1109/TBCAS.2007.893176",

language = "English (US)",

volume = "1",

pages = "63--72",

journal = "IEEE Transactions on Biomedical Circuits and Systems",

issn = "1932-4545",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

number = "1",

}

TY - JOUR

T1 - VLSI potentiostat array with oversampling gain modulation for wide-range neurotransmitter sensing

AU - Stanaćević, Milutin

AU - Murari, Kartikeya

AU - Rege, Abhishek

AU - Cauwenberghs, Gert

AU - Thakor, Nitish V.

N1 - Funding Information: Manuscript received December 16, 2006; revised January 16, 2007. This work was supported in part by the National Institutes of Health, National Institute of Aging, National Science Foundation, Defense Advanced Research Projects Agency, and the Whitaker Foundation. This paper was recommended by Editor-in-Chief T. S. Lande.

PY - 2007/3

Y1 - 2007/3

N2 - A 16-channel current-measuring very large-scale integration (VLSI) sensor array system for highly sensitive electrochemical detection of electroactive neurotransmiters like dopamine and nitric-oxide is presented. Each channel embeds a current integrating potentiostat within a switched-capacitor first-order single-bit delta-sigma modulator implementing an incremental analog-to-digital converter. The duty-cycle modulation of current feedback in the delta-sigma loop together with variable oversampling ratio provide a programmable digital range selection of the input current spanning over six orders of magnitude from picoamperes to microamperes. The array offers 100-fA input current sensitivity at 3.4-μW power consumption per channel. The operation of the 3 mm × 3 mm chip fabricated in 0.5-μm CMOS technology is demonstrated with real-time multichannel acquisition of neurotransmitter concentration.

AB - A 16-channel current-measuring very large-scale integration (VLSI) sensor array system for highly sensitive electrochemical detection of electroactive neurotransmiters like dopamine and nitric-oxide is presented. Each channel embeds a current integrating potentiostat within a switched-capacitor first-order single-bit delta-sigma modulator implementing an incremental analog-to-digital converter. The duty-cycle modulation of current feedback in the delta-sigma loop together with variable oversampling ratio provide a programmable digital range selection of the input current spanning over six orders of magnitude from picoamperes to microamperes. The array offers 100-fA input current sensitivity at 3.4-μW power consumption per channel. The operation of the 3 mm × 3 mm chip fabricated in 0.5-μm CMOS technology is demonstrated with real-time multichannel acquisition of neurotransmitter concentration.

KW - Biomedical instrumentation

KW - Correlated double sampling

KW - Current measurement

KW - Micropower techniques

KW - Potentiostat

KW - Sigma-delta modulator

KW - Switched-capacitor circuits

UR - http://www.scopus.com/inward/record.url?scp=34247853514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247853514&partnerID=8YFLogxK

U2 - 10.1109/TBCAS.2007.893176

DO - 10.1109/TBCAS.2007.893176

M3 - Article

C2 - 23851522

AN - SCOPUS:34247853514

SN - 1932-4545

VL - 1

SP - 63

EP - 72

JO - IEEE Transactions on Biomedical Circuits and Systems

JF - IEEE Transactions on Biomedical Circuits and Systems

IS - 1

ER -

VLSI potentiostat array with oversampling gain modulation for wide-range neurotransmitter sensing

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this