Vitamin E levels, cognitive impairment and dementia in older persons: The InCHIANTI study

Antonio Cherubini, Antonio Martin, Cristina Andres-Lacueva, Angelo Di Iorio, Marco Lamponi, Patrizia Mecocci, Benedetta Bartali, Annamaria Corsi, Umberto Senin, Luigi Ferrucci

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


There is conflicting evidence that antioxidants contribute to maintaining cognitive function in elderly subjects. We investigated whether vitamin E plasma levels are related to the presence of dementia and cognitive impairment in a population-based cohort study conducted in Italy. A total of 1033 participants aged at least 65 years received clinical and neuropsychological examinations, donated blood for vitamin E analysis and had their diets assessed. Participants with plasma vitamin E levels in the bottom tertile had a significantly higher probability of being demented (OR 2.6, 95% CI 1.0-7.1) and also of suffering from cognitive impairment (OR 2.2, 95% CI 1.2-4.2) compared to those in the highest vitamin E tertile after adjustment for age, gender, education, lipid levels, energy intake, vitamin E intake, and smoking. This study supports the notion that higher vitamin E plasma levels might provide significant protection against cognitive impairment and dementia in elderly subjects.

Original languageEnglish (US)
Pages (from-to)987-994
Number of pages8
JournalNeurobiology of Aging
Issue number7
StatePublished - Jul 2005
Externally publishedYes


  • Antioxidant
  • Cognitive impairment
  • Dementia
  • Elderly
  • Epidemiological study
  • Vitamin E

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • General Psychology


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