Vitamin E deficiency and enhanced platelet function: Reversal following E supplementation

A. M. Lake, M. J. Stuart, F. A. Oski

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Marked platelet hyperaggregability to adenosine diphosphate, epinephrine, and collagen was demonstrated in two children with vitamin E deficiency, with complete reversal following E supplementation. No clinical thrombotic tendency was observed during the E-deficient state. The action of vitamin E in the schema of platelet arachidonate peroxidation appears to be at the step of phospholipase A activation, or the conversion of arachidonic acid into the cyclic endoperoxides, since the peroxidation product malonaldehyde was increased during the E-deficient state with normalization following E sufficiency.

Original languageEnglish (US)
Pages (from-to)722-725
Number of pages4
JournalThe Journal of pediatrics
Issue number5
StatePublished - May 1977

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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