Vitamin E ameliorates enhanced renal lipid peroxidation and accumulation of F2-isoprostanes in aging kidneys

Jane F. Reckelhoff, Vijaya Kanji, Lorraine C. Racusen, Ann Marie Schmidt, Shu Du Yan, Jason Morrow, L. Jackson Roberts, Abdulla K. Salahudeen

Research output: Contribution to journalArticlepeer-review

96 Scopus citations


Aging results in progressive glomerular sclerosis and reductions in glomerular filtration rate (GFR). Oxidative stress may be an important mechanism for the aging process, but to date the role of oxidative stress on renal aging has not been determined. The present study was performed to determine whether age-related alterations in renal hemodynamics and morphology were associated with oxidative stress and whether this could be attenuated by chronic administration of vitamin E. Rats, aged 13 mo, were given either control diet containing vitamin E 50 IU/kg (n = 6) or a high- vitamin E diet (5,000 IU/kg; n = 6) for 9 mo. Another group of rats (3-4 mo old; n = 7) served as young controls. Aging was accompanied by a 60% reduction in GFR, a threefold increase in renal F2 isoprostanes, newly discovered vasoconstrictive F2-like prostaglandins generated by free radical-mediated lipid peroxidation. Renal aging was also associated with an increase in oxidant-sensitive heme oxygenase, advanced glycosylation end products (AGEs), and the AGE receptor, RAGE, AGE-RAGE interaction has been shown to induce oxidative stress. With high-vitamin E diet, GFR was increased by 50%, F2 isoprostanes were suppressed, and expression of heme oxygenase and RAGE was attenuated. There was also a tendency for glomerular sclerosis to be attenuated. These data demonstrate that age-related decline in renal function is accompanied by oxidative stress and that administration of antioxidants, such as vitamin E, could attenuate the decline in renal function.

Original languageEnglish (US)
Pages (from-to)R767-R774
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number3 43-3
StatePublished - Mar 1998


  • Advanced glycosylation end products
  • Free radicals
  • Glomerular filtration rate
  • Heme oxygenase

ASJC Scopus subject areas

  • General Medicine


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