Vitamin-D Synthesis and Metabolism after Ultraviolet Irradiation of Normal and Vitamin-D-Deficient Subjects

John S. Adams; Thomas L. Clemens; John A. Parrish; Michael F. Holick

doi:10.1056/NEJM198203253061206

Vitamin-D Synthesis and Metabolism after Ultraviolet Irradiation of Normal and Vitamin-D-Deficient Subjects

John S. Adams, Thomas L. Clemens, John A. Parrish, Michael F. Holick

Research output: Contribution to journal › Article › peer-review

228 Scopus citations

Abstract

THE beneficial effects of sunlight in the treatment and prevention of rickets and osteomalacia have been recognized for over 60 years.¹ However, little is known about the sequential changes in the serum concentrations of vitamin D and its metabolites after a single exposure to sunlight. In an attempt to understand these events, we monitored changes in serum concentrations of vitamin D and its metabolites, 25-hydroxyvitamin D (25-OH-D) and 1,25-dihydroxyvitamin D (1,25-(OH)₂-D), over a three-week period in normal subjects and vitamin-D-deficient patients, before and after whole-body exposure to various doses of ultraviolet radiation (UVR). We found that exposure to.

Original language	English (US)
Pages (from-to)	722-725
Number of pages	4
Journal	New England Journal of Medicine
Volume	306
Issue number	12
DOIs	https://doi.org/10.1056/NEJM198203253061206
State	Published - Mar 25 1982
Externally published	Yes

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Medicine(all)

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abstract = "THE beneficial effects of sunlight in the treatment and prevention of rickets and osteomalacia have been recognized for over 60 years.1 However, little is known about the sequential changes in the serum concentrations of vitamin D and its metabolites after a single exposure to sunlight. In an attempt to understand these events, we monitored changes in serum concentrations of vitamin D and its metabolites, 25-hydroxyvitamin D (25-OH-D) and 1,25-dihydroxyvitamin D (1,25-(OH)2-D), over a three-week period in normal subjects and vitamin-D-deficient patients, before and after whole-body exposure to various doses of ultraviolet radiation (UVR). We found that exposure to.",

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AU - Clemens, Thomas L.

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AU - Holick, Michael F.

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AB - THE beneficial effects of sunlight in the treatment and prevention of rickets and osteomalacia have been recognized for over 60 years.1 However, little is known about the sequential changes in the serum concentrations of vitamin D and its metabolites after a single exposure to sunlight. In an attempt to understand these events, we monitored changes in serum concentrations of vitamin D and its metabolites, 25-hydroxyvitamin D (25-OH-D) and 1,25-dihydroxyvitamin D (1,25-(OH)2-D), over a three-week period in normal subjects and vitamin-D-deficient patients, before and after whole-body exposure to various doses of ultraviolet radiation (UVR). We found that exposure to.

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Vitamin-D Synthesis and Metabolism after Ultraviolet Irradiation of Normal and Vitamin-D-Deficient Subjects

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