TY - JOUR
T1 - Vitamin d metabolites in aging hiv-infected men
T2 - Does inflammation play a role?
AU - Zhang, Long
AU - Brown, Todd T.
AU - Margolick, Joseph B.
AU - Witt, Mallory D.
AU - Palella, Frank J.
AU - Kingsley, Lawrence A.
AU - Hoofnagle, Andrew N.
AU - Tin, Adrienne
AU - Jacobson, Lisa P.
AU - Abraham, Alison G.
N1 - Publisher Copyright:
© 2018, Mary Ann Liebert, Inc.
PY - 2018/12
Y1 - 2018/12
N2 - The inflammatory context of HIV infection has been posited to contribute to the higher comorbidity risk noted in HIV-infected populations. One possible pathway may involve 1,25-dihydroxyvitamin D [1,25(OH) 2 D], which plays a wide biologic role in many tissues. We sought to investigate whether inflammation was associated with vitamin D metabolites in a cohort of HIV-infected (HIV+) men receiving treatment and HIV-uninfected (HIV-) men. Vitamin D metabolites, including 25-hydroxyvitamin D [25(OH)D] and 1,25(OH) 2 D, were measured along with 24 inflammatory markers among Multicenter AIDS Cohort Study participants. Exploratory factor analysis reduced inflammatory marker data to a smaller set of inflammatory processes (IPs). Multivariate linear regression was used to evaluate associations between vitamin D metabolites and IPs. There were 466 HIV+ and 100 HIV- men, who contributed 658 stored samples from 1998 to 2008. We found three IPs with IP 1 characterized by sTNF-R2, sIL-2Rα, sCD27, BAFF, sgp130, sCD14, CXCL10 (IP-10), and sIL-6R. While none of the three IPs was associated with 25(OH)D levels in either HIV+ or HIV-, higher levels of IP 1 were significantly associated with the reduced levels of 1,25(OH) 2 D in HIV+, and a similar although nonsignificant trend was seen in HIV-. The association between 1,25(OH) 2 D and inflammation found among HIV-infected men suggests a possible mechanism whereby inflammation leads to the increased comorbidity risk noted among HIV-infected individuals.
AB - The inflammatory context of HIV infection has been posited to contribute to the higher comorbidity risk noted in HIV-infected populations. One possible pathway may involve 1,25-dihydroxyvitamin D [1,25(OH) 2 D], which plays a wide biologic role in many tissues. We sought to investigate whether inflammation was associated with vitamin D metabolites in a cohort of HIV-infected (HIV+) men receiving treatment and HIV-uninfected (HIV-) men. Vitamin D metabolites, including 25-hydroxyvitamin D [25(OH)D] and 1,25(OH) 2 D, were measured along with 24 inflammatory markers among Multicenter AIDS Cohort Study participants. Exploratory factor analysis reduced inflammatory marker data to a smaller set of inflammatory processes (IPs). Multivariate linear regression was used to evaluate associations between vitamin D metabolites and IPs. There were 466 HIV+ and 100 HIV- men, who contributed 658 stored samples from 1998 to 2008. We found three IPs with IP 1 characterized by sTNF-R2, sIL-2Rα, sCD27, BAFF, sgp130, sCD14, CXCL10 (IP-10), and sIL-6R. While none of the three IPs was associated with 25(OH)D levels in either HIV+ or HIV-, higher levels of IP 1 were significantly associated with the reduced levels of 1,25(OH) 2 D in HIV+, and a similar although nonsignificant trend was seen in HIV-. The association between 1,25(OH) 2 D and inflammation found among HIV-infected men suggests a possible mechanism whereby inflammation leads to the increased comorbidity risk noted among HIV-infected individuals.
KW - Biomarker
KW - Hiv infected
KW - Inflammation
KW - Vitamin d
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U2 - 10.1089/aid.2018.0101
DO - 10.1089/aid.2018.0101
M3 - Article
AN - SCOPUS:85058631940
SN - 0889-2229
VL - 34
SP - 1067
EP - 1074
JO - AIDS research and human retroviruses
JF - AIDS research and human retroviruses
IS - 12
ER -