Vitamin D is not associated with HIV-associated neurocognitive disorder in Rakai, Uganda

Deanna Saylor; Gertrude Nakigozi; Carlos A. Pardo; Alice Kisakye; Anupama Kumar; Noeline Nakasujja; Kevin R. Robertson; Ronald H. Gray; Maria J. Wawer; Ned Sacktor

doi:10.1007/s13365-018-00719-6

Vitamin D is not associated with HIV-associated neurocognitive disorder in Rakai, Uganda

Deanna Saylor, Gertrude Nakigozi, Carlos A. Pardo, Alice Kisakye, Anupama Kumar, Noeline Nakasujja, Kevin R. Robertson, Ronald H. Gray, Maria J. Wawer, Ned Sacktor

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We investigated whether vitamin D is associated with HIV-associated neurocognitive disorder (HAND). HIV-infected (HIV+) antiretroviral therapy (ART)-naïve adults in rural Uganda underwent a neurocognitive battery for determination of HAND stage at baseline and after 2 years. Baseline serum 25-hydroxyvitamin D (25OH-D) and serum and cerebrospinal fluids (CSF) vitamin D-binding protein (VDBP) were obtained. Of the 399 participants, 4% (n = 16) were vitamin D deficient (25OH-D < 20 ng/mL). There was no association between 25OH-D, serum or CSF VDBP, and HAND stage at baseline or follow-up. Future studies in a population with higher levels of vitamin D deficiency may be warranted.

Original language	English (US)
Pages (from-to)	410-414
Number of pages	5
Journal	Journal of neurovirology
Volume	25
Issue number	3
DOIs	https://doi.org/10.1007/s13365-018-00719-6
State	Published - Jun 15 2019

Keywords

Africa
Epidemiology
HIV
HIV-associated neurocognitive disorder
Vitamin D

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cellular and Molecular Neuroscience
Virology

Access to Document

10.1007/s13365-018-00719-6

Cite this

@article{7d2de8875fed4fa7a1db93d9476b98c4,

title = "Vitamin D is not associated with HIV-associated neurocognitive disorder in Rakai, Uganda",

abstract = "We investigated whether vitamin D is associated with HIV-associated neurocognitive disorder (HAND). HIV-infected (HIV+) antiretroviral therapy (ART)-na{\"i}ve adults in rural Uganda underwent a neurocognitive battery for determination of HAND stage at baseline and after 2 years. Baseline serum 25-hydroxyvitamin D (25OH-D) and serum and cerebrospinal fluids (CSF) vitamin D-binding protein (VDBP) were obtained. Of the 399 participants, 4% (n = 16) were vitamin D deficient (25OH-D < 20 ng/mL). There was no association between 25OH-D, serum or CSF VDBP, and HAND stage at baseline or follow-up. Future studies in a population with higher levels of vitamin D deficiency may be warranted.",

keywords = "Africa, Epidemiology, HIV, HIV-associated neurocognitive disorder, Vitamin D",

author = "Deanna Saylor and Gertrude Nakigozi and Pardo, {Carlos A.} and Alice Kisakye and Anupama Kumar and Noeline Nakasujja and Robertson, {Kevin R.} and Gray, {Ronald H.} and Wawer, {Maria J.} and Ned Sacktor",

note = "Publisher Copyright: {\textcopyright} 2019, Journal of NeuroVirology, Inc.",

year = "2019",

month = jun,

day = "15",

doi = "10.1007/s13365-018-00719-6",

language = "English (US)",

volume = "25",

pages = "410--414",

journal = "Journal of neurovirology",

issn = "1355-0284",

publisher = "Springer New York",

number = "3",

}

TY - JOUR

T1 - Vitamin D is not associated with HIV-associated neurocognitive disorder in Rakai, Uganda

AU - Saylor, Deanna

AU - Nakigozi, Gertrude

AU - Pardo, Carlos A.

AU - Kisakye, Alice

AU - Kumar, Anupama

AU - Nakasujja, Noeline

AU - Robertson, Kevin R.

AU - Gray, Ronald H.

AU - Wawer, Maria J.

AU - Sacktor, Ned

PY - 2019/6/15

Y1 - 2019/6/15

N2 - We investigated whether vitamin D is associated with HIV-associated neurocognitive disorder (HAND). HIV-infected (HIV+) antiretroviral therapy (ART)-naïve adults in rural Uganda underwent a neurocognitive battery for determination of HAND stage at baseline and after 2 years. Baseline serum 25-hydroxyvitamin D (25OH-D) and serum and cerebrospinal fluids (CSF) vitamin D-binding protein (VDBP) were obtained. Of the 399 participants, 4% (n = 16) were vitamin D deficient (25OH-D < 20 ng/mL). There was no association between 25OH-D, serum or CSF VDBP, and HAND stage at baseline or follow-up. Future studies in a population with higher levels of vitamin D deficiency may be warranted.

AB - We investigated whether vitamin D is associated with HIV-associated neurocognitive disorder (HAND). HIV-infected (HIV+) antiretroviral therapy (ART)-naïve adults in rural Uganda underwent a neurocognitive battery for determination of HAND stage at baseline and after 2 years. Baseline serum 25-hydroxyvitamin D (25OH-D) and serum and cerebrospinal fluids (CSF) vitamin D-binding protein (VDBP) were obtained. Of the 399 participants, 4% (n = 16) were vitamin D deficient (25OH-D < 20 ng/mL). There was no association between 25OH-D, serum or CSF VDBP, and HAND stage at baseline or follow-up. Future studies in a population with higher levels of vitamin D deficiency may be warranted.

KW - Africa

KW - Epidemiology

KW - HIV

KW - HIV-associated neurocognitive disorder

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=85060631094&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060631094&partnerID=8YFLogxK

U2 - 10.1007/s13365-018-00719-6

DO - 10.1007/s13365-018-00719-6

M3 - Article

C2 - 30671778

AN - SCOPUS:85060631094

SN - 1355-0284

VL - 25

SP - 410

EP - 414

JO - Journal of neurovirology

JF - Journal of neurovirology

IS - 3

ER -

Vitamin D is not associated with HIV-associated neurocognitive disorder in Rakai, Uganda

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this