TY - JOUR
T1 - Vitamin D Insufficiency Is Prevalent among Pregnant African American Adolescents
AU - Davis, Lisa Mc Guire
AU - Chang, Shih Chen
AU - Mancini, Jeri
AU - Nathanson, Maureen Schulman
AU - Witter, Frank R.
AU - O'Brien, Kimberly O.
N1 - Funding Information:
We would like to thank and acknowledge the adolescents who volunteered to participate in this study. S.C.C. was responsible for study coordination. L.D.M. was responsible for data analysis and manuscript preparation. K.O.O. was the principal investigator of the study and was involved in the design, interpretation and manuscript preparation. M.S..N collected the dietary information from these adolescents. J.M. is the nurse midwife who provided medical care to the subjects attending this clinic and assisted in data collection. F.W. is the Director of the Labor and Delivery Suite and assisted in manuscript preparation, interpretation, and study design. We would also like to acknowledge the laboratory assistance provided by Bridgette Williams. None of the authors have any financial or personal relationships with the sponsor of this research. Supported by NIH grant HD35191.
PY - 2010/2
Y1 - 2010/2
N2 - Study Objective: Recent attention has focused on vitamin D insufficiency but few data exist on vitamin D status among pregnant minority youth. Design: A screening study was undertaken in adolescents having prenatal blood samples drawn for other routine tests obtained during the second trimester (18 ± 1.8 week gestation, n = 44) or third trimester of pregnancy (28.4 ± 2.1 week gestation, n = 36). Serum 25- hydroxyvitamin D (25(OH)D) was measured and significant determinants of vitamin D insufficiency in this cohort were identified. Setting: Urban prenatal clinic. Participants: Eighty pregnant African American adolescents (≤ 18 y of age). Main Outcome Measure(s): Vitamin D status, STDs, hemoglobin, season, birth weight. Results: Serum 25(OH)D in this group averaged 21.6 ± 8 ng/mL (age 16.5 ± 1.1 y, n = 80), and did not significantly differ between the second (20.95 ± 8.2 ng/mL, n = 44) and third trimester cohorts (22.5 ± 7.9 ng/mL, n = 36). Vitamin D insufficiency (< 20 ng/mL) was evident in 46.25% and vitamin D deficiency (<15 ng/mL) was evident in 21.25% of those studied. Significant predictors of suboptimal vitamin D status included sampling during the winter months (P = 0.004), lower hemoglobin concentration (P = 0.019), and higher second trimester leptin levels (P = 0.018). Inverse associations between 25(OH)D and bacterial vaginosis were evident when controlled for season of sampling (P = 0.02, n = 80). Conclusions: Vitamin D insufficiency was prevalent among urban pregnant minority adolescents. Further studies are needed to address the impact of this finding on maternal and neonatal calcium homeostasis and bone health.
AB - Study Objective: Recent attention has focused on vitamin D insufficiency but few data exist on vitamin D status among pregnant minority youth. Design: A screening study was undertaken in adolescents having prenatal blood samples drawn for other routine tests obtained during the second trimester (18 ± 1.8 week gestation, n = 44) or third trimester of pregnancy (28.4 ± 2.1 week gestation, n = 36). Serum 25- hydroxyvitamin D (25(OH)D) was measured and significant determinants of vitamin D insufficiency in this cohort were identified. Setting: Urban prenatal clinic. Participants: Eighty pregnant African American adolescents (≤ 18 y of age). Main Outcome Measure(s): Vitamin D status, STDs, hemoglobin, season, birth weight. Results: Serum 25(OH)D in this group averaged 21.6 ± 8 ng/mL (age 16.5 ± 1.1 y, n = 80), and did not significantly differ between the second (20.95 ± 8.2 ng/mL, n = 44) and third trimester cohorts (22.5 ± 7.9 ng/mL, n = 36). Vitamin D insufficiency (< 20 ng/mL) was evident in 46.25% and vitamin D deficiency (<15 ng/mL) was evident in 21.25% of those studied. Significant predictors of suboptimal vitamin D status included sampling during the winter months (P = 0.004), lower hemoglobin concentration (P = 0.019), and higher second trimester leptin levels (P = 0.018). Inverse associations between 25(OH)D and bacterial vaginosis were evident when controlled for season of sampling (P = 0.02, n = 80). Conclusions: Vitamin D insufficiency was prevalent among urban pregnant minority adolescents. Further studies are needed to address the impact of this finding on maternal and neonatal calcium homeostasis and bone health.
KW - Bone
KW - Calcium
KW - Diet
KW - Minority
KW - Teenage pregnancy
KW - Vitamin D
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U2 - 10.1016/j.jpag.2009.05.005
DO - 10.1016/j.jpag.2009.05.005
M3 - Article
C2 - 19643639
AN - SCOPUS:72449181724
SN - 1083-3188
VL - 23
SP - 45
EP - 52
JO - Journal of pediatric and adolescent gynecology
JF - Journal of pediatric and adolescent gynecology
IS - 1
ER -