Vitamin D adsorption in healthy subjects and in patients with intestinal malabsorption syndromes

C. W. Lo, P. W. Paris, T. L. Clemens

Research output: Contribution to journalArticlepeer-review

145 Scopus citations


We developed a test procedure for the clinical evaluation of the absorption of vitamin D. Serum vitamin D concentrations were evaluated in seven patients with intestinal fat malabsorption syndromes and in seven healthy, normal subjects, after being given a single oral dose of 50,000 IU (1.25 mg) vitamin D2. In the normal subjects, serum vitamin D concentrations rose from a baseline of less than 5 ng/ml to a peak over 50 ng/ml by 12 h, gradually falling to baseline levels by 3 days. In five of the seven patients with intestinal fat malabsorption, oral administration of 50,000 IU vitamin D2 did not raise serum vitamin D concentrations above 10 ng/ml. Two patients with severe inflammatory bowel disease had a normal absorption pattern, however. These findings suggest that an oral vitamin D absorption test may be of value for determination of patients at risk for development of vitamin D deficiency. Thay also raise questions about the efficacy of oral vitamin D preparations in patients with intestial fat malabsorption.

Original languageEnglish (US)
Pages (from-to)644-649
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Issue number4
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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