Vitamin C for neuroprotection in neonatal encephalopathy

Abstract: In this commentary, we provide additional context to interpret the findings reported on the manuscript by Liu et al., “Neuroprotective effects of vitamin C on hypoxic-ischemic brain injury in neonatal mice” published in this issue of Pediatric Research. Impact: Vitamin C is an anti-oxidant with anti-inflammatory effects, which may be neuroprotective against neonatal hypoxic-ischemic (HI) brain injury in a preterm mouse model Several experimental caveats include the timing of intervention, model use and side effects. We provide additional context to the reader in the interpretation of the data.