Vitamin B12 levels in the prolonged use of sodium nitroprusside

J. Lipman, C. Hesdorffer, F. Fernandes Costa

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Long-term (> 48 h) sodium nitroprusside (SNP) infusion significantly reduced cobalamin (vitamin B12) levels in 23 patients treated in a CCU after myocardial infarction. There was no evidence of vitamin B12 deficiency or SNP toxicity. Low vitamin B12 levels should not limit the use of SNP, because prolonged infusion of SNP at maximum doses of 2.5 μg/kg.min did not adversely affect hemodynamic stability.

Original languageEnglish (US)
Pages (from-to)161-163
Number of pages3
JournalCritical care medicine
Issue number3
StatePublished - 1984

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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