Vitamin a, vitamin e, iron and zinc status in a cohort of hiv-infected mothers and their uninfected infants

Jacqueline Pontes Monteiro, Maria Letícia Santos Cruz, Marisa Márcia Mussi-Pinhata, Roberta Garcia Salomão, Alceu Jordão Junior, Laura Freimanis Hance, Jennifer Suzanne Read, José Henrique Silva Da Pilotto, Rachel Ann Cohen, Sonia Karolina Stoszek, George Kelly Siberry

Research output: Contribution to journalArticlepeer-review


Introduction: We hypothesized that nutritional defi ciency would be common in a cohort of postpartum, human immunodefi ciency virus (HIV)-infected women and their infants. Methods: Weight and height, as well as blood concentrations of retinol, α-tocopherol, ferritin, hemoglobin, and zinc, were measured in mothers after delivery and in their infants at birth and at 6-12 weeks and six months of age. Retinol and α-tocopherol levels were quantifi ed by high performance liquid chromatography, and zinc levels were measured by atomic absorption spectrophotometry. The maternal body mass index during pregnancy was adjusted for gestational age (adjBMI). Results: Among the 97 women 19.6% were underweight. Laboratory abnormalities were most frequently observed for the hemoglobin (46.4%), zinc (41.1%), retinol (12.5%) and ferritin (6.5%) levels. Five percent of the women had mean corpuscular hemoglobin concentrations < 31g/dL. The most common defi ciency in the infants was α-tocopherol (81%) at birth; however, only 18.5% of infants had defi cient levels at six months of age. Large percentages of infants had zinc (36.8%) and retinol (29.5%) defi ciencies at birth; however, these percentages decreased to 17.5% and 18.5%, respectively, by six months of age. No associations between infant micronutrient defi ciencies and either the maternal adjBMI category or maternal micronutrient defi ciencies were found. Conclusions: Micronutrient defi ciencies were common in HIVinfected women and their infants. Micronutrient defi ciencies were less prevalent in the infants at six months of age. Neither underweight women nor their infants at birth were at increased risk for micronutrient deficiencies.

Original languageEnglish (US)
Pages (from-to)692-700
Number of pages9
JournalRevista da Sociedade Brasileira de Medicina Tropical
Issue number6
StatePublished - 2014


  • Cohort
  • HIV infection
  • Infant
  • Micronutrients
  • Nutrition
  • Pregnancy

ASJC Scopus subject areas

  • Parasitology
  • Microbiology (medical)
  • Infectious Diseases


Dive into the research topics of 'Vitamin a, vitamin e, iron and zinc status in a cohort of hiv-infected mothers and their uninfected infants'. Together they form a unique fingerprint.

Cite this