Visualization of dopamine nerve terminals by positron tomography using [18F]fluoro-β-fluomethylene-m-tyrosine

O. T. DeJesus; J. E. Holden; C. Endres; D. Murali; T. R. Oakes; S. Shelton; Hideo Uno; D. Houser; L. Freund; S. B. Perlman; R. J. Nickles

doi:10.1016/0006-8993(92)91518-J

Visualization of dopamine nerve terminals by positron tomography using [¹⁸F]fluoro-β-fluomethylene-m-tyrosine

O. T. DeJesus
, J. E. Holden
, C. Endres
, D. Murali
, T. R. Oakes
, S. Shelton
, Hideo Uno
, D. Houser
, L. Freund
, S. B. Perlman
, R. J. Nickles

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

[¹⁸F]-6-Fluoro-β-fluoromethylene-m-tyrosine ([¹⁸F]FFMMT) was evaluated as a potential imaging agent for dopamine nerve terminals using positron emission tomography (PET). Biodistribution and time course of this tracer in mice after i.p. injection was consistent with the distribution of dopamine. PET imaging studies involving rhesus macaques showed specific uptake in the dopamine-rich caudate-putamen region. This specific localization was blocked by inhibiting the enzyme l-aromatic amino acid decarboxylase and the transport of the tracer into brain was shown to be stereospecific. These results show the promise of l-[¹⁸F]FFMMT as a PET tracer in monitoring degeneration of the CNS dopamine system.

Original language	English (US)
Pages (from-to)	151-154
Number of pages	4
Journal	Brain Research
Volume	597
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(92)91518-J
State	Published - Nov 27 1992
Externally published	Yes

Keywords

Dopamine nerve terminal
MDL 72394
Parkinson's disease
Positron emission tomography
[F]Fluoro-β-fluoromethylene-m-tyrosine

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(92)91518-J

Cite this

@article{63a133bd75d24331ae0cb433cb43eac4,

title = "Visualization of dopamine nerve terminals by positron tomography using [18F]fluoro-β-fluomethylene-m-tyrosine",

abstract = "[18F]-6-Fluoro-β-fluoromethylene-m-tyrosine ([18F]FFMMT) was evaluated as a potential imaging agent for dopamine nerve terminals using positron emission tomography (PET). Biodistribution and time course of this tracer in mice after i.p. injection was consistent with the distribution of dopamine. PET imaging studies involving rhesus macaques showed specific uptake in the dopamine-rich caudate-putamen region. This specific localization was blocked by inhibiting the enzyme l-aromatic amino acid decarboxylase and the transport of the tracer into brain was shown to be stereospecific. These results show the promise of l-[18F]FFMMT as a PET tracer in monitoring degeneration of the CNS dopamine system.",

keywords = "Dopamine nerve terminal, MDL 72394, Parkinson's disease, Positron emission tomography, [F]Fluoro-β-fluoromethylene-m-tyrosine",

author = "DeJesus, \{O. T.\} and Holden, \{J. E.\} and C. Endres and D. Murali and Oakes, \{T. R.\} and S. Shelton and Hideo Uno and D. Houser and L. Freund and Perlman, \{S. B.\} and Nickles, \{R. J.\}",

year = "1992",

month = nov,

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doi = "10.1016/0006-8993(92)91518-J",

language = "English (US)",

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pages = "151--154",

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T1 - Visualization of dopamine nerve terminals by positron tomography using [18F]fluoro-β-fluomethylene-m-tyrosine

AU - DeJesus, O. T.

AU - Holden, J. E.

AU - Endres, C.

AU - Murali, D.

AU - Oakes, T. R.

AU - Shelton, S.

AU - Uno, Hideo

AU - Houser, D.

AU - Freund, L.

AU - Perlman, S. B.

AU - Nickles, R. J.

PY - 1992/11/27

Y1 - 1992/11/27

N2 - [18F]-6-Fluoro-β-fluoromethylene-m-tyrosine ([18F]FFMMT) was evaluated as a potential imaging agent for dopamine nerve terminals using positron emission tomography (PET). Biodistribution and time course of this tracer in mice after i.p. injection was consistent with the distribution of dopamine. PET imaging studies involving rhesus macaques showed specific uptake in the dopamine-rich caudate-putamen region. This specific localization was blocked by inhibiting the enzyme l-aromatic amino acid decarboxylase and the transport of the tracer into brain was shown to be stereospecific. These results show the promise of l-[18F]FFMMT as a PET tracer in monitoring degeneration of the CNS dopamine system.

AB - [18F]-6-Fluoro-β-fluoromethylene-m-tyrosine ([18F]FFMMT) was evaluated as a potential imaging agent for dopamine nerve terminals using positron emission tomography (PET). Biodistribution and time course of this tracer in mice after i.p. injection was consistent with the distribution of dopamine. PET imaging studies involving rhesus macaques showed specific uptake in the dopamine-rich caudate-putamen region. This specific localization was blocked by inhibiting the enzyme l-aromatic amino acid decarboxylase and the transport of the tracer into brain was shown to be stereospecific. These results show the promise of l-[18F]FFMMT as a PET tracer in monitoring degeneration of the CNS dopamine system.

KW - Dopamine nerve terminal

KW - MDL 72394

KW - Parkinson's disease

KW - Positron emission tomography

KW - [F]Fluoro-β-fluoromethylene-m-tyrosine

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