Visualization of brown adipose tissue with 99mTc- methoxyisobutylisonitrile on SPECT/CT

Sibyll Goetze, William C. Lavely, Harvey A. Ziessman, Richard L. Wahl

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Brown adipose tissue (BAT) is retained into adulthood in some patients. It has been imaged using several radiopharmaceuticals, including 18F-FDG. Using SPECT/CT, we assessed whether and how frequently uptake of 99mTc-methoxyisobutylisonitrile (99mTc-MIBI) was present in expected locations of BAT. Methods: A total of 205 SPECT/CT scans using 99mTc-MIBI for parathyroid imaging were reviewed for the presence of 99mTc-MIBI uptake in expected locations of BAT. Results: We detected 99mTc-MIBI uptake in BAT in 13 of 205 patients (6.3%). When BAT was visualized, it was detected on both early and delayed scans. The patients with 99mTc-MIBI uptake in BAT were younger than the patients with no 99mTc-MIBI uptake (P = 0.044). Conclusion: Uptake of 99mTc-MIBI in BAT is relatively common in this adult patient population and should not be confused with 99mTc-MIBI-avid-tumors. SPECT/CT can be useful for defining such tracer uptake as a normal physiologic variant.

Original languageEnglish (US)
Pages (from-to)752-756
Number of pages5
JournalJournal of Nuclear Medicine
Issue number5
StatePublished - May 1 2008
Externally publishedYes


  • Brown adipose tissue
  • Hybrid imaging
  • Tc- methoxyisobutylisonitrile

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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