Virulence-associated enzymes of Cryptococcus neoformans

Fausto Almeida, Julie M. Wolf, Arturo Casadevall

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations


Enzymes play key roles in fungal pathogenesis. Manipulation of enzyme expression or activity can significantly alter the infection process, and enzyme expression profiles can be a hallmark of disease. Hence, enzymes are worthy targets for better understanding pathogenesis and identifying new options for combatting fungal infections. Advances in genomics, proteomics, transcriptomics, and mass spectrometry have enabled the identification and characterization of new fungal enzymes. This review focuses on recent developments in the virulence-associated enzymes from Cryptococcus neoformans. The enzymatic suite of C. neoformans has evolved for environmental survival, but several of these enzymes play a dual role in colonizing the mammalian host. We also discuss new therapeutic and diagnostic strategies that could be based on the underlying enzymology.

Original languageEnglish (US)
Pages (from-to)1173-1185
Number of pages13
JournalEukaryotic Cell
Issue number12
StatePublished - 2015

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology


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