TY - JOUR
T1 - Vibrational spectroscopy for decoding cancer microbiota interactions
T2 - Current evidence and future perspective
AU - Liu, Zhenhui
AU - Parida, Sheetal
AU - Prasad, Ram
AU - Pandey, Rishikesh
AU - Sharma, Dipali
AU - Barman, Ishan
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2022/11
Y1 - 2022/11
N2 - The role of human microbiota in cancer initiation and progression is recognized in recent years. In order to investigate the interactions between cancer cells and microbes, a systematic analysis using various emerging techniques is required. Owing to the label-free, non-invasive and molecular fingerprinting characteristics, vibrational spectroscopy is uniquely suited to decode and understand the relationship and interactions between cancer and the microbiota at the molecular level. In this review, we first provide a quick overview of the fundamentals of vibrational spectroscopic techniques, namely Raman and infrared spectroscopy. Next, we discuss the emerging evidence underscoring utilities of these spectroscopic techniques to study cancer or microbes separately, and share our perspective on how vibrational spectroscopy can be employed at the intersection of the two fields. Finally, we envision the potential opportunities in exploiting vibrational spectroscopy not only in basic cancer-microbiome research but also in its clinical translation, and discuss the challenges in the bench to bedside translation.
AB - The role of human microbiota in cancer initiation and progression is recognized in recent years. In order to investigate the interactions between cancer cells and microbes, a systematic analysis using various emerging techniques is required. Owing to the label-free, non-invasive and molecular fingerprinting characteristics, vibrational spectroscopy is uniquely suited to decode and understand the relationship and interactions between cancer and the microbiota at the molecular level. In this review, we first provide a quick overview of the fundamentals of vibrational spectroscopic techniques, namely Raman and infrared spectroscopy. Next, we discuss the emerging evidence underscoring utilities of these spectroscopic techniques to study cancer or microbes separately, and share our perspective on how vibrational spectroscopy can be employed at the intersection of the two fields. Finally, we envision the potential opportunities in exploiting vibrational spectroscopy not only in basic cancer-microbiome research but also in its clinical translation, and discuss the challenges in the bench to bedside translation.
KW - Cancer
KW - Human microbiota
KW - Raman spectroscopy
KW - Ramanome
KW - Vibrational spectroscopy
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U2 - 10.1016/j.semcancer.2021.07.004
DO - 10.1016/j.semcancer.2021.07.004
M3 - Review article
C2 - 34273519
AN - SCOPUS:85111510663
SN - 1044-579X
VL - 86
SP - 743
EP - 752
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
ER -