TY - JOUR
T1 - Vibration sensitivity recovery after a second course of acrylamide intoxication
AU - Maurissen, Jacques P.J.
AU - Wess, Bernard
AU - Cox, Christopher
PY - 1990/7
Y1 - 1990/7
N2 - Vibration Sensitivity Recovery after a Second Course of Acrylamide Intoxication. MAURISSEN. J. P. J., WEISS, B., AND COX, C. (1990). Fundam Appl. Toxicol 15, 93-98. Five monkeys were trained to report detection of vibration or an electrical stimulus. Three of them had been dosed previously with acrylamide administered orally until toxic signs appeared, and were then allowed to recover. Approximately 30 weeks after the end of the first dosing course, they were dosed a second time with 10 mg/kg/day of acrylamide, 5 days a week, to mimic the dosage regimen of the first dosing period. Two monkeys received vehicle, as in the first dosing period. Vibration sensitivity was reduced in the exposed monkeys to an extent comparable to the first dosing period. Analysis of covariance showed that the rate of recovery from a second exposure to acrylamide was comparable to the rate of recovery from the first exposure. Vibration sensitivity appears useful as a monitoring tool to follow the time course of acrylamide-induced peripheral nerve dysfunction.
AB - Vibration Sensitivity Recovery after a Second Course of Acrylamide Intoxication. MAURISSEN. J. P. J., WEISS, B., AND COX, C. (1990). Fundam Appl. Toxicol 15, 93-98. Five monkeys were trained to report detection of vibration or an electrical stimulus. Three of them had been dosed previously with acrylamide administered orally until toxic signs appeared, and were then allowed to recover. Approximately 30 weeks after the end of the first dosing course, they were dosed a second time with 10 mg/kg/day of acrylamide, 5 days a week, to mimic the dosage regimen of the first dosing period. Two monkeys received vehicle, as in the first dosing period. Vibration sensitivity was reduced in the exposed monkeys to an extent comparable to the first dosing period. Analysis of covariance showed that the rate of recovery from a second exposure to acrylamide was comparable to the rate of recovery from the first exposure. Vibration sensitivity appears useful as a monitoring tool to follow the time course of acrylamide-induced peripheral nerve dysfunction.
UR - http://www.scopus.com/inward/record.url?scp=0025016040&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025016040&partnerID=8YFLogxK
U2 - 10.1093/toxsci/15.1.93
DO - 10.1093/toxsci/15.1.93
M3 - Article
C2 - 2373303
AN - SCOPUS:0025016040
SN - 1096-6080
VL - 15
SP - 93
EP - 98
JO - Toxicological Sciences
JF - Toxicological Sciences
IS - 1
ER -