@article{0e852095f1e9490db4b0539eb903631b,
title = "Vestibular and oculomotor abnormalities among HIV-infected and HIV-uninfected men and women: A pilot study",
abstract = "OBJECTIVE: To determine if middle-aged and aging men and women with HIV disease (HIV+) should be screened for vestibular and oculomotor dysfunction. METHODS: Age- and sociodemographically matched HIV+ and HIV- men and women were tested on vestibular evoked myogenic potential (VEMP), bi-thermic caloric testing, Dix-Hallpike maneuvers and saccades. RESULTS: HIV+ men had more caloric weakness than HIV- men. HIV+ subjects had more saccade abnormalities than HIV- subjects. A saccade abnormality was positively associated with being HIV+. Among the HIV+ sample, abnormalities were associated with increasing age, being male, ever taking monotherapy, and having an undetectable viral load. Only being male and having an undetectable viral load were statistically significant. Unilateral caloric weakness had a decreased prevalence with age per 10 years, and being HIV+ showed an increased prevalence. In HIV+ subjects only, these abnormalities decreased with age and being male but increased with undetectable viral load and ever taking antiretroviral monotherapy. No statistically significant differences were found. CONCLUSION: Women are at greater risk of vestibular and oculomotor abnormalities than men. HIV+ adults are at greater risk than HIV- adults. Physicians who care for HIV+ men and women should monitor the symptoms of vestibular and oculomotor impairment.",
keywords = "VEMP, Vestibular testing, bi-thermal caloric test, inner ear, screening, vestibular epidemiology",
author = "Pichert, {Matthew D.} and Plankey, {Michael W.} and Gayle Springer and Christopher Cox and Hoffman, {Howard J.} and Cohen, {Helen S.}",
note = "Funding Information: This work was supported by R01-DC009031 (HS Cohen). Data in this manuscript were collected by the Washington, DC site of the Women{\textquoteright}s Interagency HIV Study and the Baltimore-Washington, DC site of the Multicenter AIDS Cohort Study, now the MACS/WIHS Combined Cohort Study (MWCCS). The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). MWCCS (Principal Investigators Data Analysis and Coordination Center (Gypsyamber D{\textquoteright}Souza, Stephen Gange and Elizabeth Golub), U01-HL146193; Metropolitan Washington CRS (Seble Kassaye and Daniel Merenstein), U01-HL146205; Baltimore-Washington, DC CRS (Joseph Margolick and Todd Brown); U01-HL14620. The MWCCS is funded primarily by the National Heart, Lung, and Blood Institute (NHLBI), with additional co-funding from the Eunice Kennedy Shriver National Institute Of Child Health & Human Development (NICHD), National Human Genome Research Institute (NHGRI), National Institute On Aging (NIA), National Institute Of Dental & Craniofacial Research (NIDCR), National Institute Of Allergy And Infectious Diseases (NIAID), National Institute Of Neurological Disorders And Stroke (NINDS), National Institute Of Mental Health (NIMH), National Institute On Drug Abuse (NIDA), National Institute Of Nursing Research (NINR), National Cancer Institute (NCI), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). MWCCS Funding Information: This work was supported by R01-DC009031 (HS Cohen). Data in this manuscript were collected by the Washington, DC site of the Women's Interagency HIV Study and the Baltimore-Washington, DC site of the Multicenter AIDS Cohort Study, now the MACS/WIHS Combined Cohort Study (MWCCS).The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH).MWCCS(Principal Investigators Data Analysis and Coordination Center (Gypsyamber D'Souza, Stephen Gange and Elizabeth Golub), U01- HL146193; Metropolitan Washington CRS (Seble Kassaye and Daniel Merenstein), U01-HL146205; Baltimore-Washington, DC CRS (Joseph Margolick and Todd Brown); U01-HL14620. The MWCCS is funded primarily by the National Heart, Lung, and Blood Institute (NHLBI), with additional cofunding from the Eunice Kennedy Shriver National Institute Of Child Health & Human Development (NICHD), National Human Genome Research Institute (NHGRI), National Institute On Aging (NIA), National Institute Of Dental & Craniofacial Research (NIDCR), National Institute Of Allergy And Infectious Diseases (NIAID), National Institute Of Neurological Disorders And Stroke (NINDS), National Institute Of Mental Health (NIMH), National Institute On Drug Abuse (NIDA), National Institute Of Nursing Research (NINR), National Cancer Institute (NCI), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). MWCCS data collection is also supported by UL1-TR000004 (UCSF CTSA), P30-AI-050409 (Atlanta CFAR), P30-AI-050410 (UNC CFAR), and P30-AI-027767 (UAB CFAR). We are indebted to the Baltimore- Washington, DC men and women participants for providing data used in this study. The authors want to thank the audiologists and staff within the Division of Audiology at Georgetown University Medical Center for their implementation and data collection support for this study. Publisher Copyright: {\textcopyright} 2020 - IOS Press and the authors. All rights reserved.",
year = "2020",
doi = "10.3233/VES-200707",
language = "English (US)",
volume = "30",
pages = "329--334",
journal = "Journal of Vestibular Research: Equilibrium and Orientation",
issn = "0957-4271",
publisher = "IOS Press",
number = "5",
}