Abstract
(Matrix presented) meso-Aryloxy- and alkoxy-substituted porphyrins were conveniently synthesized by direct reactions of meso-halogenated porphyrins with alcohols via palladium-catalyzed C-O cross-coupling reactions. Using a combination of palladium precursor Pd(OAc)2 or Pd 2(dba)3 and phosphine ligand DPEphos or Xantphos allowed both 5-bromo-10,20-diarylporphyrin and 5,15-dibromo-10,20-diarylporphyrin, as well as their zinc complexes, to be effectively coupled with a variety of alcohols to give the corresponding mono- and bis-substituted meso-aryloxylalkoxyporphyrins in moderate to high yields under mild conditions.
Original language | English (US) |
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Pages (from-to) | 3261-3264 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 5 |
Issue number | 18 |
DOIs | |
State | Published - Sep 4 2003 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry