Vascular cognitive change: Perspective from neurology

Guy M. McKhann, Ola A. Selnes

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


In summary, the interaction between vascular changes and Alzheimer's disease is a critical question that remains to be fully elucidated. On the basis of the evidence to date, it is logical to assume that any given individual with dementia might have some degree of vascular pathology and some degree of Alzheimer's disease pathology. Current diagnostic paradigms do not go far enough in terms of differentiating underlying pathologies; only brain imaging, MRI in particular, can reveal subsymptomatic cerebrovascular changes. Similarly, there are scant evidence-based data to guide clinicians in the treatment of vascular dementia or mixed dementia that might be primarily a result of, or worsened by, vascular pathology. The existing data do suggest that preventing further cerebrovascular disease, whether silent or symptomatic stroke or small vessel disease, is one clear strategy for intervening to potentially reduce the burden of cognitive impairment and dementia.

Original languageEnglish (US)
Pages (from-to)S23-S29
JournalAlzheimer's and Dementia
Issue number2 SUPPL.
StatePublished - Apr 2007

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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